Team's Publications in Scientific Journals

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2017

DL Santos Ferreira, DM Williams, AJ Kangas, P Soininen, M Ala-Korpela, G Davey Smith, M-R Järvelin, DA Lawlor Association of pre-pregnancy body mass index with future offspring metabolic profile: findings from three independent European prospective birth cohorts with a negative control study PLoS Medicine 2017, accepted

M Fizelova, R Jauhiainen, AJ Kangas, P Soininen, M Ala-Korpela, J Kuusisto, M Laakso, A Stančáková Differential associations of inflammatory markers with insulin sensitivity and secretion: the prospective METSIM study Journal of Clinical Endocrinology & Metabolism 2017, in press

ME Cannon, Q Duan, Y Wu, M Zeynalzadeh, Z Xu, AJ Kangas, P Soininen, M Ala-Korpela, M Civelek, AJ Lusis, J Kuusisto, FS Collins, M Boehnke, H Tang, M Laakso, Y Li, KL Mohlke Trans-ancestry fine mapping and molecular assays identify regulatory variants at the ANGPTL8 HDL-C GWAS locus G3: Genes, Genomes, Genetics 2017, accepted

AP Nath, SC Ritchie, SG Byars, LG Fearnley, AS Havulinna, A Joensuu, AJ Kangas, P Soininen, A Wennerström, L Milani, A Metspalu, S Männistö, P Würtz, J Kettunen, E Raitoharju, M Kähönen, M Juonala, A Palotie, M Ala-Korpela, S Ripatti, T Lehtimäki, G Abraham, OT Raitakari, V Salomaa, M Perola, M Inouye An interaction map of circulating metabolites, immune gene networks and their genetic regulation Genome Biology 2017, accepted

FZ Marques, PR Prestes, SG Byars, SC Ritchie, P Würtz, SK Patel, SA Booth, I Rana, Y Minoda, SP Berzins, C Curl, JR Bell, B Wai, PM Srivastava, AJ Kangas, P Soininen, S Ruohonen, M Kähönen, T Lehtimäki, E Raitoharju, A Havulinna, M Perola, OT Raitakari, V Salomaa, M Ala-Korpela, J Kettunen, M McGlynn, J Kelly, ME Wlodek, PA Lewandowski, LM Delbridge, LM Burrell, M Inouye, SB Harrap, FJ Charchar Experimental and human evidence for Lipocalin‐2 (Neutrophil Gelatinase‐Associated Lipocalin [NGAL]) in the development of cardiac hypertrophy and heart failure Journal of the American Heart Association 6, e005971, 2017

MV Holmes, M Ala-Korpela, G Davey Smith Mendelian randomization in cardiometabolic disease: challenges in evaluating causality Nature Reviews Cardiology 1. Jun [Epub ahead of print], 2017

A Couto Alves, B Valcarcel, V-P Mäkinen, L Morin-Papunen, S Sebert, AJ Kangas, P Soininen, S Das, M De Iorio, L Coin, M Ala-Korpela, M-R Järvelin, S Franks Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity International Journal of Obesity 26. May [Epub ahead of print], 2017

DS Kim, AU Jackson, YK Li, HM Stringham, FinMetSeq investigators, J Kuusisto, AJ Kangas, P Soininen, M Ala-Korpela, CF Burant, V Salomaa, M Boehnke, M Laakso, EK Speliotes Novel association of TM6SF2 rs58542926 genotype with increased serum tyrosine levels and decreased apolipoprotein B-100 particles in Finns Journal of Lipid Research 58, 1471-1481, 2017

P Würtz, AJ Kangas, P Soininen, DA Lawlor, G Davey Smith, M Ala-Korpela Quantitative serum NMR metabolomics in large-scale epidemiology: a primer on -omic technology American Journal of Epidemiology 10. May [Epub ahead of print], 2017

E Org, Y Blum, S Kasela, M Mehrabian, J Kuusisto, AJ Kangas, P Soininen, Z Wang, M Ala-Korpela, SL Hazen, M Laakso, AJ Lusis Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort Genome Biology 18, 70, 2017

R Lithovius, I Toppila, V Harjutsalo, C Forsblom, PH Groop, VP Mäkinen, FinnDiane Study Group Data-driven metabolic subtypes predict future adverse events in individuals with type 1 diabetes Diabetologia 60, 1234-1243, 2017

T Paavola, S Kuusisto, M Jauhiainen, S Kakko, T Kangas-Kontio, J Metso, P Soininen, M Ala-Korpela, R Bloigu, ML Hannuksela, MJ Savolainen, T Salonurmi Impaired HDL2-mediated cholesterol efflux is associated with metabolic syndrome in families with early onset coronary heart disease and low HDL-cholesterol level PLOS ONE 12, e0171993, 2017

E Marouli, M Graff, C Medina-Gomez, KS Lo, AR Wood, TR Kjaer, RS Fine, Y Lu, C Schurmann, HM Highland, S Rüeger, G Thorleifsson, AE Justice, D Lamparter, KE Stirrups, V Turcot, KL Young, TW Winkler, T Esko, T Karaderi, AE Locke, NG Masca, MC Ng, P Mudgal, MA Rivas, S Vedantam, A Mahajan, X Guo, G Abecasis, KK Aben, LS Adair, DS Alam, E Albrecht, KH Allin, M Allison, P Amouyel, EV Appel, D Arveiler, FW Asselbergs, PL Auer, B Balkau, B Banas, LE Bang, M Benn, S Bergmann, LF Bielak, M Blüher, H Boeing, E Boerwinkle, CA Böger, LL Bonnycastle, J Bork-Jensen, ML Bots, EP Bottinger, DW Bowden, I Brandslund, G Breen, MH Brilliant, L Broer, AA Burt, AS Butterworth, DJ Carey, MJ Caulfield, JC Chambers, DI Chasman, YI Chen, R Chowdhury, C Christensen, AY Chu, M Cocca, FS Collins, JP Cook, J Corley, JC Galbany, AJ Cox, G Cuellar-Partida, J Danesh, G Davies, PI de Bakker, GJ de Borst, S de Denus, MC de Groot, R de Mutsert, IJ Deary, G Dedoussis, EW Demerath, AI den Hollander, JG Dennis, E Di Angelantonio, F Drenos, M Du, AM Dunning, DF Easton, T Ebeling, TL Edwards, PT Ellinor, P Elliott, E Evangelou, AE Farmaki, JD Faul, MF Feitosa, S Feng, E Ferrannini, MM Ferrario, J Ferrieres, JC Florez, I Ford, M Fornage, PW Franks, R Frikke-Schmidt, TE Galesloot, W Gan, I Gandin, P Gasparini, V Giedraitis, A Giri, G Girotto, SD Gordon, P Gordon-Larsen, M Gorski, N Grarup, ML Grove, V Gudnason, S Gustafsson, T Hansen, KM Harris, TB Harris, AT Hattersley, C Hayward, L He, IM Heid, K Heikkilä, Ø Helgeland, J Hernesniemi, AW Hewitt, LJ Hocking, M Hollensted, OL Holmen, GK Hovingh, JM Howson, CB Hoyng, PL Huang, K Hveem, MA Ikram, E Ingelsson, AU Jackson, JH Jansson, GP Jarvik, GB Jensen, MA Jhun, Y Jia, X Jiang, S Johansson, ME Jørgensen, T Jørgensen, P Jousilahti, JW Jukema, B Kahali, RS Kahn, M Kähönen, PR Kamstrup, S Kanoni, J Kaprio, M Karaleftheri, SL Kardia, F Karpe, F Kee, R Keeman, LA Kiemeney, H Kitajima, KB Kluivers, T Kocher, P Komulainen, J Kontto, JS Kooner, C Kooperberg, P Kovacs, J Kriebel, H Kuivaniemi, S Küry, J Kuusisto, M La Bianca, M Laakso, TA Lakka, EM Lange, LA Lange, CD Langefeld, C Langenberg, EB Larson, IT Lee, T Lehtimäki, CE Lewis, H Li, J Li, R Li-Gao, H Lin, LA Lin, X Lin, L Lind, J Lindström, A Linneberg, Y Liu, Y Liu, A Lophatananon, J Luan, SA Lubitz, LP Lyytikäinen, DA Mackey, PA Madden, AK Manning, S Männistö, G Marenne, J Marten, NG Martin, AL Mazul, K Meidtner, A Metspalu, P Mitchell, KL Mohlke, DO Mook-Kanamori, A Morgan, AD Morris, AP Morris, M Müller-Nurasyid, PB Munroe, MA Nalls, M Nauck, CP Nelson, M Neville, SF Nielsen, K Nikus, PR Njølstad, BG Nordestgaard, I Ntalla, JR O'Connel, H Oksa, LM Loohuis, RA Ophoff, KR Owen, CJ Packard, S Padmanabhan, CN Palmer, G Pasterkamp, AP Patel, A Pattie, O Pedersen, PL Peissig, GM Peloso, CE Pennell, M Perola, JA Perry, JR Perry, TN Person, A Pirie, O Polasek, D Posthuma, OT Raitakari, A Rasheed, R Rauramaa, DF Reilly, AP Reiner, F Renström, PM Ridker, JD Rioux, N Robertson, A Robino, O Rolandsson, I Rudan, KS Ruth, D Saleheen, V Salomaa, NJ Samani, K Sandow, Y Sapkota, N Sattar, MK Schmidt, PJ Schreiner, MB Schulze, RA Scott, MP Segura-Lepe, S Shah, X Sim, S Sivapalaratnam, KS Small, AV Smith, JA Smith, L Southam, TD Spector, EK Speliotes, JM Starr, V Steinthorsdottir, HM Stringham, M Stumvoll, P Surendran, LM 't Hart, KE Tansey, JC Tardif, KD Taylor, A Teumer, DJ Thompson, U Thorsteinsdottir, BH Thuesen, A Tönjes, G Tromp, S Trompet, E Tsafantakis, J Tuomilehto, A Tybjaerg-Hansen, JP Tyrer, R Uher, AG Uitterlinden, S Ulivi, SW van der Laan, AR Van Der Leij, CM van Duijn, NM van Schoor, J van Setten, A Varbo, TV Varga, R Varma, DR Edwards, SH Vermeulen, H Vestergaard, V Vitart, TF Vogt, D Vozzi, M Walker, F Wang, CA Wang, S Wang, Y Wang, NJ Wareham, HR Warren, J Wessel, SM Willems, JG Wilson, DR Witte, MO Woods, Y Wu, H Yaghootkar, J Yao, P Yao, LM Yerges-Armstrong, R Young, E Zeggini, X Zhan, W Zhang, JH Zhao, W Zhao, W Zhao, H Zheng, W Zhou, EPIC-InterAct Consortium, CHD Exome+ Consortium, ExomeBP Consortium, T2D-Genes Consortium, GoT2D Genes Consortium, Global Lipids Genetics Consortium, ReproGen Consortium, MAGIC Investigators, JI Rotter, M Boehnke, S Kathiresan, MI McCarthy, CJ Willer, K Stefansson, IB Borecki, DJ Liu, KE North, NL Heard-Costa, TH Pers, CM Lindgren, C Oxvig, Z Kutalik, F Rivadeneira, RJ Loos, TM Frayling, JN Hirschhorn, P Deloukas, G Lettre Rare and low-frequency coding variants alter human adult height Nature 542, 186-190, 2017

HR Warren, E Evangelou, CP Cabrera, H Gao, M Ren, B Mifsud, I Ntalla, P Surendran, C Liu, JP Cook, AT Kraja, F Drenos, M Loh, N Verweij, J Marten, I Karaman, MP Lepe, PF O'Reilly, J Knight, H Snieder, N Kato, J He, ES Tai, MA Said, D Porteous, M Alver, N Poulter, M Farrall, RT Gansevoort, S Padmanabhan, R Mägi, A Stanton, J Connell, SJ Bakker, A Metspalu, DC Shields, S Thom, M Brown, P Sever, T Esko, C Hayward, P van der Harst, D Saleheen, R Chowdhury, JC Chambers, DI Chasman, A Chakravarti, C Newton-Cheh, CM Lindgren, D Levy, JS Kooner, B Keavney, M Tomaszewski, NJ Samani, JM Howson, MD Tobin, PB Munroe, GB Ehret, LV Wain, International Consortium of Blood Pressure (ICBP) 1000G Analyses, BIOS Consortium, Lifelines Cohort Study, Understanding Society Scientific group, CHD Exome+ Consortium, ExomeBP Consortium, T2D-GENES Consortium, GoT2DGenes Consortium, Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium,International Genomics of Blood Pressure (iGEN-BP) Consortium, UK Biobank CardioMetabolic Consortium BP working group Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk Nature Genetics 49, 403-415, 2017

F Drenos Mechanistic insights from combining genomics with metabolomics Current Opinion in Lipidology 28, 99-103, 2017

N Bidargaddi, P Musiat, VP Makinen, M Ermes, G Schrader, J Licinio Digital footprints: facilitating large-scale environmental psychiatric research in naturalistic settings through data from everyday technologies Molecular Psychiatry 22, 164-169, 2017

S Wahl, A Drong, B Lehne, M Loh, WR Scott, S Kunze, P-C Tsai, JS Ried, W Zhang, Y Yang, S Tan, G Fiorito, L Franke, S Guarrera, S Kasela, J Kriebel, RC Richmond, M Adamo, U Afzal, M Ala-Korpela, B Albetti, O Ammerpohl, JF Apperley, M Beekman, PA Bertazzi, SL Black, C Blancher, M-J Bonder, M Brosch, M Carstensen-Kirberg, AJM De Craen, S de Lusignan, A Dehghan, M Elkalaawy, K Fischer, O Franco, TR Gaunt, J Hampe, M Hashemi, A Isaacs, A Jenkinson, S Jha, N Kato, V Krogh, M Laffan, C Meisinger, T Meitinger, ZY Mok, V Motta, HK Ng, Z Nikolakopoulou, G Nteliopoulos, S Panico, N Pervjakova, H Prokisch, W Rathmann, M Roden, F Rota, MA Rozario, JK Sandling, C Schafmayer, K Schramm, R Siebert, PE Slagboom, P Soininen, L Stolk, K Strauch, E-S Tai, L Tarantini, B Thorand, EF Tigchelaar, R Tumino, AG Uitterlinden, C van Duijn, JBJ van Meurs, P Vineis, AR Wickremasinghe, C Wijmenga, T-P Yang, W Yuan, A Zhernakova, R Batterham, GD Smith, P Deloukas, BT Heijmans, C Herder, A Hofman, CM Lindgren, L Milani, P van der Harst, A Peters, T Illig, CL Relton, M Waldenberger, M-R Järvelin, V Bollati, R Soong, TD Spector, J Scott, MI McCarthy, P Elliott, JT Bell, G Matullo, C Gieger, JS Kooner, H Grallert, JC Chambers Epigenome-wide association study for body mass index and adiposity measures Nature 541, 81–86, 2017

AV Ahola-Olli, P Würtz, AS Havulinna, K Aalto, N Pitkänen, T Lehtimäki, M Kähönen, LP Lyytikäinen, E Raitoharju, I Seppälä, AP Sarin, S Ripatti, A Palotie, M Perola, JS Viikari, S Jalkanen, M Maksimow, V Salomaa, M Salmi, J Kettunen, OT Raitakari Genome-wide association study identifies 27 loci influencing concentrations of circulating cytokines and growth factors American Journal of Human Genetics 100, 40-50, 2017

VP Mäkinen Challenges in conducting genetic analyses based on data-driven classification of major depressive disorder Molecular Psychiatry 8. Nov 2016 [Epub ahead of print], 2017

JE Kaikkonen, P Würtz, E Suomela, M Oikonen, M Lehtovirta, AJ Kangas, A Jula, V Mikkilä, JSA Viikari, M Juonala, T Rönnemaa, N Hutri-Kähönen, M Kähönen, T Lehtimäki, P Soininen, M Ala-Korpela, OT Raitakari Metabolic profiling of fatty liver disease in young and middle-aged adults ­– cross-sectional and prospective analyses of the Young Finns Study Hepatology 65, 491-500, 2017

R De, SS Verma, E Holzinger, M Hall, A Burt, DS Carrell, DR Crosslin, GP Jarvik, H Kuivaniemi, IJ Kullo, LA Lange, MB Lanktree, EB Larson, KE North, AP Reiner, V Tragante, G Tromp, JG Wilson, FW Asselbergs, F Drenos, JH Moore, MD Ritchie, B Keating, D Gilbert-Diamond Identifying gene-gene interactions that are highly associated with four quantitative lipid traits across multiple cohorts Human Genetics 136, 165-178, 2017

T Peltonen, P Ohukainen, H Ruskoaho, J Rysä Targeting vasoactive peptides for managing calcific aortic valve disease Annals of Medicine 49, 63-74, 2017

2016

Q Wang, P Würtz, K Auro, VP Mäkinen, AJ Kangas, P Soininen, M Tiainen, T Tynkkynen, J Jokelainen, K Santalahti, M Salmi, S Blankenberg, T Zeller, J Viikari, M Kähönen, T Lehtimäki, V Salomaa, M Perola, S Jalkanen, MR Järvelin, OT Raitakari, J Kettunen, DA Lawlor, M Ala-Korpela Metabolic profiling of pregnancy: Cross-sectional and longitudinal evidence BMC Medicine 14, 205, 2016

E Raitoharju, I Seppälä, L-P Lyytikäinen, J Viikari, M Ala-Korpela, P Soininen, AJ Kangas, M Waldenberger, N Klopp, T Illig, J Leiviskä, B-M Loo, N Oksala, M Kähönen, N Hutri-Kähönen, R Laaksonen, OT Raitakari, T Lehtimäki Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism ­ The Young Finns Study Scientific Reports 6, 38262, 2016

J Gillberg, P Marttinen, M Pirinen, AJ Kangas, P Soininen, M Ali, AS Havulinna, MR Järvelin, M Ala-Korpela, S Kaski Multiple output regression with latent noise Journal of Machine Learning Research 17, 1-35, 2016

L Shu, Y Zhao, Z Kurt, SG Byars, T Tukiainen, J Kettunen, LD Orozco, M Pellegrini, AJ Lusis, S Ripatti, B Zhang, M Inouye, VP Mäkinen, X Yang Mergeomics: multidimensional data integration to identify pathogenic perturbations to biological systems BMC Genomics 4, 874, 2016

H Säkkinen, J Aro, L Kaikkonen, P Ohukainen, J Näpänkangas, H Tokola, H Ruskoaho, J Rysä Mitogen-activated protein kinase p38 target regenerating islet-derived 3γ expression is upregulated in cardiac inflammatory response in the rat heart Physiological Reports 4, e12996, 2016

S Lemmelä, S Solovieva, R Shiri, C Benner, M Heliövaara, J Kettunen, V Anttila, S Ripatti, M Perola, I Seppälä, M Juonala, M Kähönen, V Salomaa, J Viikari, OT Raitakari, T Lehtimäki, A Palotie, E Viikari-Juntura, K Husgafvel-Pursiainen Genome-wide meta-analysis of sciatica in Finnish population PLOS ONE 11, e0163877, 2016

D Arneson, A Bhattacharya, L Shu, VP Mäkinen, X Yang Mergeomics: a web server for identifying pathological pathways, networks, and key regulators via multidimensional data integration BMC Genomics 17, 722, 2016

GB Ehret, T Ferreira, DI Chasman, AU Jackson, EM Schmidt, T Johnson, G Thorleifsson, J Luan, LA Donnelly, S Kanoni, AK Petersen, V Pihur, RJ Strawbridge, D Shungin, MF Hughes, O Meirelles, M Kaakinen, N Bouatia-Naji, K Kristiansson, S Shah, ME Kleber, X Guo, LP Lyytikäinen, C Fava, N Eriksson, IM Nolte, PK Magnusson, EL Salfati, LS Rallidis, E Theusch, AJ Smith, L Folkersen, K Witkowska, TH Pers, R Joehanes, SK Kim, L Lataniotis, R Jansen, AD Johnson, H Warren, YJ Kim, W Zhao, Y Wu, BO Tayo, M Bochud, , , , D Absher, LS Adair, N Amin, DE Arking, T Axelsson, D Baldassarre, B Balkau, S Bandinelli, MR Barnes, I Barroso, S Bevan, JC Bis, G Bjornsdottir, M Boehnke, E Boerwinkle, LL Bonnycastle, DI Boomsma, SR Bornstein, MJ Brown, M Burnier, CP Cabrera, JC Chambers, IS Chang, CY Cheng, PS Chines, RH Chung, FS Collins, JM Connell, A Döring, J Dallongeville, J Danesh, U de Faire, G Delgado, AF Dominiczak, AS Doney, F Drenos, S Edkins, JD Eicher, R Elosua, S Enroth, J Erdmann, P Eriksson, T Esko, E Evangelou, A Evans, T Fall, M Farrall, JF Felix, J Ferrières, L Ferrucci, M Fornage, T Forrester, N Franceschini, OH Franco, A Franco-Cereceda, RM Fraser, SK Ganesh, H Gao, K Gertow, F Gianfagna, B Gigante, F Giulianini, A Goel, AH Goodall, MO Goodarzi, M Gorski, J Gräßler, CJ Groves, V Gudnason, U Gyllensten, G Hallmans, AL Hartikainen, M Hassinen, AS Havulinna, C Hayward, S Hercberg, KH Herzig, AA Hicks, AD Hingorani, JN Hirschhorn, A Hofman, J Holmen, OL Holmen, JJ Hottenga, P Howard, CA Hsiung, SC Hunt, MA Ikram, T Illig, C Iribarren, RA Jensen, M Kähönen, HM Kang, S Kathiresan, BJ Keating, KT Khaw, YK Kim, E Kim, M Kivimaki, N Klopp, G Kolovou, P Komulainen, JS Kooner, G Kosova, RM Krauss, D Kuh, Z Kutalik, J Kuusisto, K Kvaløy, TA Lakka, NR Lee, IT Lee, WJ Lee, D Levy, X Li, KW Liang, H Lin, L Lin, J Lindström, S Lobbens, S Männistö, G Müller, M Müller-Nurasyid, F Mach, HS Markus, E Marouli, MI McCarthy, CA McKenzie, P Meneton, C Menni, A Metspalu, V Mijatovic, L Moilanen, ME Montasser, AD Morris, AC Morrison, A Mulas, R Nagaraja, N Narisu, K Nikus, CJ O'Donnell, PF O'Reilly, KK Ong, F Paccaud, CD Palmer, A Parsa, NL Pedersen, BW Penninx, M Perola, A Peters, N Poulter, PP Pramstaller, BM Psaty, T Quertermous, DC Rao, A Rasheed, NW Rayner, F Renström, R Rettig, KM Rice, R Roberts, LM Rose, J Rossouw, NJ Samani, S Sanna, J Saramies, H Schunkert, S Sebert, WH Sheu, YA Shin, X Sim, JH Smit, AV Smith, MX Sosa, TD Spector, A Stančáková, AV Stanton, KE Stirrups, HM Stringham, J Sundstrom, AJ Swift, AC Syvänen, ES Tai, T Tanaka, KV Tarasov, A Teumer, U Thorsteinsdottir, MD Tobin, E Tremoli, AG Uitterlinden, M Uusitupa, A Vaez, D Vaidya, CM van Duijn, EP van Iperen, RS Vasan, GC Verwoert, J Virtamo, V Vitart, BF Voight, P Vollenweider, A Wagner, LV Wain, NJ Wareham, H Watkins, AB Weder, HJ Westra, R Wilks, T Wilsgaard, JF Wilson, TY Wong, TP Yang, J Yao, L Yengo, W Zhang, JH Zhao, X Zhu, P Bovet, RS Cooper, KL Mohlke, D Saleheen, JY Lee, P Elliott, HJ Gierman, CJ Willer, L Franke, GK Hovingh, KD Taylor, G Dedoussis, P Sever, A Wong, L Lind, TL Assimes, I Njølstad, PE Schwarz, C Langenberg, H Snieder, MJ Caulfield, O Melander, M Laakso, J Saltevo, R Rauramaa, J Tuomilehto, E Ingelsson, T Lehtimäki, K Hveem, W Palmas, W März, M Kumari, V Salomaa, YI Chen, JI Rotter, P Froguel, MR Jarvelin, EG Lakatta, K Kuulasmaa, PW Franks, A Hamsten, HE Wichmann, CN Palmer, K Stefansson, PM Ridker, RJ Loos, A Chakravarti, P Deloukas, AP Morris, C Newton-Cheh, PB Munroe The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals Nature Genetics 48, 1171-1184, 2016

C Liu, AT Kraja, JA Smith, JA Brody, N Franceschini, JC Bis, K Rice, AC Morrison, Y Lu, S Weiss, X Guo, W Palmas, LW Martin, YI Chen, P Surendran, F Drenos, JP Cook, PL Auer, AY Chu, A Giri, W Zhao, J Jakobsdottir, LA Lin, JM Stafford, N Amin, H Mei, J Yao, A Voorman, MG Larson, ML Grove, AV Smith, SJ Hwang, H Chen, T Huan, G Kosova, NO Stitziel, S Kathiresan, N Samani, H Schunkert, P Deloukas, M Li, C Fuchsberger, C Pattaro, M Gorski, C Kooperberg, GJ Papanicolaou, JE Rossouw, JD Faul, SL Kardia, C Bouchard, LJ Raffel, AG Uitterlinden, OH Franco, RS Vasan, CJ O'Donnell, KD Taylor, K Liu, EP Bottinger, O Gottesman, EW Daw, F Giulianini, S Ganesh, E Salfati, TB Harris, LJ Launer, M Dörr, SB Felix, R Rettig, H Völzke, E Kim, WJ Lee, IT Lee, WH Sheu, KS Tsosie, DR Edwards, Y Liu, A Correa, DR Weir, U Völker, PM Ridker, E Boerwinkle, V Gudnason, AP Reiner, CM van Duijn, IB Borecki, TL Edwards, A Chakravarti, JI Rotter, BM Psaty, RJ Loos, M Fornage, GB Ehret, C Newton-Cheh, D Levy, DI Chasman Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci Nature Genetics 48, 1162-1170, 2016

P Surendran, F Drenos, R Young, H Warren, JP Cook, AK Manning, N Grarup, X Sim, DR Barnes, K Witkowska, JR Staley, V Tragante, T Tukiainen, H Yaghootkar, N Masca, DF Freitag, T Ferreira, O Giannakopoulou, A Tinker, M Harakalova, E Mihailov, C Liu, AT Kraja, SF Nielsen, A Rasheed, M Samuel, W Zhao, LL Bonnycastle, AU Jackson, N Narisu, AJ Swift, L Southam, J Marten, JR Huyghe, A Stančáková, C Fava, T Ohlsson, A Matchan, KE Stirrups, J Bork-Jensen, AP Gjesing, J Kontto, M Perola, S Shaw-Hawkins, AS Havulinna, H Zhang, LA Donnelly, CJ Groves, NW Rayner, MJ Neville, NR Robertson, AM Yiorkas, KH Herzig, E Kajantie, W Zhang, SM Willems, L Lannfelt, G Malerba, N Soranzo, E Trabetti, N Verweij, E Evangelou, A Moayyeri, AC Vergnaud, CP Nelson, A Poveda, TV Varga, M Caslake, AJ de Craen, S Trompet, J Luan, RA Scott, SE Harris, DC Liewald, R Marioni, C Menni, AE Farmaki, G Hallmans, F Renström, JE Huffman, M Hassinen, S Burgess, RS Vasan, JF Felix, M Uria-Nickelsen, A Malarstig, DF Reilly, M Hoek, TF Vogt, H Lin, W Lieb, M Traylor, HS Markus, , HM Highland, AE Justice, E Marouli, , J Lindström, M Uusitupa, P Komulainen, TA Lakka, R Rauramaa, O Polasek, I Rudan, O Rolandsson, PW Franks, G Dedoussis, TD Spector, P Jousilahti, S Männistö, IJ Deary, JM Starr, C Langenberg, NJ Wareham, MJ Brown, AF Dominiczak, JM Connell, JW Jukema, N Sattar, I Ford, CJ Packard, T Esko, R Mägi, A Metspalu, RA de Boer, P van der Meer, P van der Harst, G Gambaro, E Ingelsson, L Lind, PI de Bakker, ME Numans, I Brandslund, C Christensen, ER Petersen, E Korpi-Hyövälti, H Oksa, JC Chambers, JS Kooner, AI Blakemore, S Franks, MR Jarvelin, LL Husemoen, A Linneberg, T Skaaby, B Thuesen, F Karpe, J Tuomilehto, AS Doney, AD Morris, CN Palmer, OL Holmen, K Hveem, CJ Willer, T Tuomi, L Groop, A Käräjämäki, A Palotie, S Ripatti, V Salomaa, DS Alam, AA Majumder, E Di Angelantonio, R Chowdhury, MI McCarthy, N Poulter, AV Stanton, P Sever, P Amouyel, D Arveiler, S Blankenberg, J Ferrières, F Kee, K Kuulasmaa, M Müller-Nurasyid, G Veronesi, J Virtamo, P Deloukas, P Elliott, E Zeggini, S Kathiresan, O Melander, J Kuusisto, M Laakso, S Padmanabhan, DJ Porteous, C Hayward, G Scotland, FS Collins, KL Mohlke, T Hansen, O Pedersen, M Boehnke, HM Stringham, P Frossard, C Newton-Cheh, MD Tobin, BG Nordestgaard, MJ Caulfield, A Mahajan, AP Morris, M Tomaszewski, NJ Samani, D Saleheen, FW Asselbergs, CM Lindgren, J Danesh, LV Wain, AS Butterworth, JM Howson, PB Munroe Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension Nature Genetics 48, 1151-1161, 2016

P Würtz, Q Wang, M Niironen, T Tynkkynen, M Tiainen, F Drenos, AJ Kangas, P Soininen, MR Skilton, K Heikkilä, A Pouta, M Kähönen, T Lehtimäki, RJ Rose, E Kajantie, M Perola, J Kaprio, JG Eriksson, OT Raitakari, DA Lawlor, G Davey Smith, M-R Järvelin, M Ala-Korpela, K Auro Metabolic signatures of birth weight in 18 288 adolescents and adults International Journal of Epidemiology 45, 1539-1550, 2016

P Würtz, S Cook, Q Wang, M Tiainen, T Tynkkynen, AJ Kangas, P Soininen, J Laitinen, J Viikari, M Kähönen, T Lehtimäki, M Perola,S Blankenberg, T Zeller, S Männistö, V Salomaa, M-R Järvelin, OT Raitakari, M Ala-Korpela, DA Leon Metabolic profiling of alcohol consumption in 9778 young adults International Journal of Epidemiology 45, 1493-1506, 2016

S Vogt, S Wahl, J Kettunen, S Breitner, G Kastenmüller, C Gieger, K Suhre, M Waldenberger, J Kratzsch, M Perola, V Salomaa, S Blankenberg, T Zeller, P Soininen, AJ Kangas, A Peters, H Grallert, M Ala-Korpela, B Thorand Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D ­ A cross-sectional analysis in population-based data International Journal of Epidemiology 45, 1469-1481, 2016

Q Wang, P Würtz, K Auro, L Morin-Papunen, AJ Kangas, P Soininen, M Tiainen, T Tynkkynen, A Joensuu, AS Havulinna, K Aalto, M Salmi, S Blankenberg, T Zeller, J Viikari, M Kähönen, T Lehtimäki, V Salomaa, S Jalkanen, M-R Järvelin, M Perola, OT Raitakari, DA Lawlor, J Kettunen, M Ala-Korpela Effects of hormonal contraception on systemic metabolism: Cross-sectional and longitudinal evidence International Journal of Epidemiology 45, 1445-1457, 2016

M Ala-Korpela, G Davey Smith Metabolic profiling ­– multitude of technologies with great research potential, but (when) will translation emerge? (Editorial for the Themed Issue on Metabolic Phenotyping in Epidemiology) International Journal of Epidemiology 45, 1311-1316, 2016

SW van der Laan, T Fall, A Soumaré, A Teumer, S Sedaghat, J Baumert, D Zabaneh, J van Setten, I Isgum, TE Galesloot, J Arpegård, P Amouyel, S Trompet, M Waldenberger, M Dörr, PK Magnusson, V Giedraitis, A Larsson, AP Morris, JF Felix, AC Morrison, N Franceschini, JC Bis, M Kavousi, C O'Donnell, F Drenos, V Tragante, PB Munroe, R Malik, M Dichgans, BB Worrall, J Erdmann, CP Nelson, NJ Samani, H Schunkert, J Marchini, RS Patel, AD Hingorani, L Lind, NL Pedersen, J de Graaf, LA Kiemeney, SE Baumeister, OH Franco, A Hofman, AG Uitterlinden, W Koenig, C Meisinger, A Peters, B Thorand, JW Jukema, BO Eriksen, I Toft, T Wilsgaard, NC Onland-Moret, YT van der Schouw, S Debette, M Kumari, P Svensson, P van der Harst, M Kivimaki, BJ Keating, N Sattar, A Dehghan, AP Reiner, E Ingelsson, HM den Ruijter, PI de Bakker, G Pasterkamp, J Ärnlöv, MV Holmes, FW Asselbergs Cystatin C and cardiovascular disease: A mendelian randomization study JACC – Journal of the American College of Cardiology 68, 934-45, 2016

KE Beaney, JA Cooper, S McLachlan, SG Wannamethee, BJ Jefferis, P Whincup, Y Ben-Shlomo, JF Price, M Kumari, A Wong, K Ong, R Hardy, D Kuh, M Kivimaki, AJ Kangas, P Soininen, M Ala-Korpela, F Drenos, SE Humphries, UCLEB consortium Variant rs10911021 that associates with coronary heart disease in type 2 diabetes mellitus, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids Cardiovascular Diabetology 15, 115, 2016

H Koivisto, H Leinonen, M Puurula, HS Hafez, GA Barrera, MH Stridh, HS Waagepetersen, M Tiainen, P Soininen, Y Zilberter, H Tanila Chronic pyruvate supplementation increases exploratory activity and brain energy reserves in young and middle-aged mice Frontiers in Aging Neuroscience 8, 41, 2016

M Ala-Korpela Metabolomics in cardiovascular medicine – not personalised, not diagnostic (Letter to AC Dona et al. Eur J Prev Cardiol 2016) European Journal of Preventive Cardiology 23, 1821-1822, 2016

A Palomäki, V Hällberg, M Ala-Korpela, PT Kovanen, K Malminiemi Prompt impact of prospective statin mega-trials on postoperative lipid management of CABG patients: a 20-year follow-up in a single hospital Lipids in Health and Disease 15, 124, 2016

V-P Mäkinen, M Ala-Korpela Metabolomics of aging requires large-scale longitudinal studies with replication (Letter to R. Chaleckis et al. PNAS 113, 4252–4259, 2016) PNAS - Proceedings of the National Academy of Sciences of the United States of America 113, E3470, 2016

S McLachlan, C Giambartolomei, J White, P Charoen, A Wong, C Finan, J Engmann, T Shah, M Hersch, C Podmore, A Cavadino, BJ Jefferis, CE Dale, E Hypponen, RW Morris, JP Casas, M Kumari, Y Ben-Shlomo, TR Gaunt, F Drenos, C Langenberg, D Kuh, M Kivimaki, R Rueedi, G Waeber, AD Hingorani, JF Price, AP Walker, UCLEB Consortium Replication and characterization of association between ABO SNPs and red blood cell traits by meta-analysis in Europeans PLOS ONE 11, e0156914, 2016

P Walle, M Takkunen, V Männistö, M Vaittinen, M Lankinen, V Kärjä, P Käkelä, J Ågren, M Tiainen, U Schwab, J Kuusisto, M Laakso, J Pihlajamäki Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity Metabolism: Clinical and Experimental 65, 655-66, 2016

M Leusink, AH Maitland-van der Zee, B Ding, F Drenos, EP van Iperen, HR Warren, MJ Caulfield, LA Cupples, M Cushman, AD Hingorani, RC Hoogeveen, GK Hovingh, M Kumari, LA Lange, PB Munroe, F Nyberg, PJ Schreiner, S Sivapalaratnam, PI de Bakker, A de Boer, BJ Keating, FW Asselbergs, NC Onland-Moret A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering Pharmacogenomics 17, 583-91, 2016

RW Morris, JA Cooper, T Shah, A Wong, F Drenos, J Engmann, S McLachlan, B Jefferis, C Dale, R Hardy, D Kuh, Y Ben-Shlomo, SG Wannamethee, PH Whincup, JP Casas, M Kivimaki, M Kumari, PJ Talmud, JF Price, F Dudbridge, AD Hingorani, SE Humphries, UCLEB Consortium Marginal role for 53 common genetic variants in cardiovascular disease prediction Heart 102, 1640-1647, 2016

F Drenos, G Davey Smith, M Ala-Korpela, J Kettunen, P Würtz, P Soininen, AJ Kangas, C Dale, DA Lawlor, TR Gaunt, J-P Casas, N Timpson Metabolic characterisation of a rare genetic variation within APOC3 and its lipoprotein lipase independent effects Circulation: Cardiovascular Genetics 9, 231-239, 2016

V Aho, HM Ollila, E Kronholm, I Bondia-Pons, P Soininen, AJ Kangas, M Hilvo, I Seppälä, J Kettunen, M Oikonen, E Raitoharju, T Hyötyläinen, M Kähönen, JSA Viikari, M Härmä, M Sallinen, VM Olkkonen, H Alenius, M Jauhiainen, T Paunio, T Lehtimäki, V Salomaa, M Orešič, OT Raitakari, M Ala-Korpela, T Porkka-Heiskanen Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses Scientific Reports 6, 24828, 2016

A Cichonska, J Rousu, P Marttinen, AJ Kangas, P Soininen, T Lehtimäki, OT Raitakari, M-R Järvelin, V Salomaa, M Ala-Korpela, S Ripatti, M Pirinen metaCCA: Summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis Bioinformatics 32, 1981-1989, 2016

J Kettunen, A Demirkan, P Würtz, HHM Draisma, T Haller, R Rawal, A Vaarhorst, AJ Kangas, LP Lyytikäinen, M Pirinen, R Pool, AP Sarin, P Soininen, T Tukiainen, Q Wang, M Tiainen, T Tynkkynen, N Amin, T Zeller, M Beekman, J Deelen, KW van Dijk, JJ Hottenga,EM van Leeuwen, T Lehtimäki, E Mihailov, RJ Rose, AJM de Craen, C Gieger, M Kähönen, M Perola, Blankenberg S, Savolainen MJ, Verhoeven A, Viikari J, Willemsen G, Boomsma DI, van Duijn CM, Eriksson J, Jula A, Järvelin MR, Kaprio J, Metspalu A, Raitakari O, Salomaa V, PE Slagboom, M Waldenberger, S Ripatti, M Ala-Korpela Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA Nature Communications 7, 11122, 2016

F Oldoni, J Palmen, C Giambartolomei, P Howard, F Drenos, V Plagnol, SE Humphries, PJ Talmud, AJ Smith Post-GWAS methodologies for localisation of functional non-coding variants: ANGPTL3 Atherosclerosis 246, 193-201, 2016

D Preiss, N Rankin, SM Lloyd, P Welsh, RR Holman, AJ Kangas, P Soininen, P Würtz, M Ala-Korpela, N Sattar The effect of metformin therapy on circulating amino acids in a randomised trial: the CAMERA study Diabetic Medicine 33, 1569-1574, 2016

P Würtz, Q Wang, P Soininen, AJ Kangas, G Fatemifar, T Tynkkynen, M Tiainen, M Perola, T Tillin, AD Hughes, P Mäntyselkä, M Kähönen, T Lehtimäki, N Sattar, AD Hingorani, J-P Casas, V Salomaa, M Kivimäki, M-R Järvelin, G Davey Smith, M Vanhala, DA Lawlor, OT Raitakari, N Chaturvedi, J Kettunen, M Ala-Korpela Metabolomic profiling of statin use and genetic inhibition of HMG-CoA reductase JACC – Journal of the American College of Cardiology 67, 1200-1210, 2016

HM Ollila, E Kronholm, J Kettunen, K Silander, M Perola, T Porkka-Heiskanen, V Salomaa, T Paunio Insomnia does not mediate or modify the association between MTNR1B risk variant rs10830963 and glucose levels Diabetologia 59, 1070-1072, 2016

A Kyttälä, R Moraghebi, C Valensisi, J Kettunen, C Andrus, K Pasumarthy, M Nakanishi, K Nishimura, M Ohtaka, J Weltner, B Van Handel, O Parkkonen, J Sinisalo, A Jalanko, RD Hawkins, NB Woods, T Otonkoski, R Trokovic Genetic variability overrides the impact of parental cell-type and determines iPSCs differentiation potential Stem Cell Reports 6, 200-212, 2016

J White, R Sofat, G Hemani, T Shah, J Engmann, C Dale, S Shah, FA Kruger, C Giambartolomei, DI Swerdlow, T Palmer, S McLachlan, C Langenberg, D Zabaneh, R Lovering, A Cavadino, B Jefferis, C Finan, A Wong, A Amuzu, K Ong, TR Gaunt, H Warren, T-L Davies, F Drenos, J Cooper, S Ebrahim, DA Lawlor, PJ Talmud, SE Humphries, C Power, E Hypponen, M Richards, R Hardy, D Kuh, N Wareham, Y Ben-Shlomo, IN Day, P Whincup, R Morris, MWJ Strachan, J Price, M Kumari, M Kivimaki, V Plagnol, JC Whittaker, ICBP, GD Smith, F Dudbridge, JP Casas, MV Holmes, AD Hingorani, UCLEB Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis The Lancet Diabetes & Endocrinology 4, 327-336, 2016

PP Laurila, J Soronen, S Kooijman, S Forsström, MR Boon, I Surakka, E Kaiharju, CP Coomans, SA Van Den Berg, A Autio, AP Sarin, J Kettunen, E Tikkanen, T Manninen, J Metso, R Silvennoinen, K Merikanto, M Ruuth, J Perttilä, A Mäkelä, A Isomi, AM Tuomainen, A Tikka, UA Ramadan, I Seppälä, T Lehtimäki, J Eriksson, A Havulinna, A Jula, PJ Karhunen, V Salomaa, M Perola, C Ehnholm, M Lee-Rueckert, M Van Eck, A Roivainen, MR Taskinen, L Peltonen, E Mervaala, A Jalanko, E Hohtola, VM Olkkonen, S Ripatti, PT Kovanen, PC Rensen, A Suomalainen, M Jauhiainen USF1 deficiency activates brown adipose tissue and improves cardiometabolic health Science Translational Medicine 8, 323ra13, 2016

JE Kaikkonen, P Kresanov, M Ahotupa, A Jula, V Mikkilä, JSA Viikari, M Juonala, N Hutri-Kähönen, M Kähönen, T Lehtimäki, AJ Kangas, P Soininen, M Ala-Korpela, OT Raitakari Longitudinal study of circulating oxidized LDL and HDL and fatty liver: the Cardiovascular Risk in Young Finns Study Free Radical Research 50, 396-404, 2016

LH Bogl, SM Kaye, J Rämö, AJ Kangas, P Soininen, A Hakkarainen, J Lundbom, N Lundbom, A Ortega-Alonso, A Rissanen, M Ala-Korpela, J Kaprio, KH Pietiläinen Abdominal obesity and circulating metabolites: a twin study approach Metabolism: Clinical and Experimental 65, 111-121, 2016

D Gordin, L Bernardi, M Rosengård-Bärlund, VP Mäkinen, A Soro-Paavonen, C Forsblom, A Sandelin, PH Groop Oxygen deteriorates arterial function in type 1 diabetes Acta Diabetologica 53, 349-357, 2016

E Nüesch, C Dale, TM Palmer, J White, BJ Keating, EP van Iperen, A Goel, S Padmanabhan, FW Asselbergs, WM Verschuren, C Wijmenga, YT Van der Schouw, NC Onland-Moret, LA Lange, GK Hovingh, S Sivapalaratnam, RW Morris, PH Whincup, GS Wannamethe, TR Gaunt, S Ebrahim, L Steel, N Nair, AP Reiner, C Kooperberg, JF Wilson, JL Bolton, S McLachlan, JF Price, MW Strachan, CM Robertson, ME Kleber, G Delgado, W März, O Melander, AF Dominiczak, M Farrall, H Watkins, M Leusink, AH Maitland-van der Zee, MC de Groot, F Dudbridge, A Hingorani, Y Ben-Shlomo, DA Lawlor, A Amuzu, M Caufield, A Cavadino, J Cooper, TL Davies, F Drenos, J Engmann, C Finan, C Giambartolomei, R Hardy, SE Humphries, E Hypponen, M Kivimaki, D Kuh, M Kumari, K Ong, V Plagnol, C Power, M Richards, S Shah, T Shah, R Sofat, PJ Talmud, N Wareham, H Warren, JC Whittaker, A Wong, D Zabaneh, G Davey Smith, JC Wells, DA Leon, MV Holmes, JP Casas Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis International Journal of Epidemiology 45, 1927-1937, 2016

2015

R De, SS Verma, F Drenos, ER Holzinger, MV Holmes, MA Hall, DR Crosslin, DS Carrell, H Hakonarson, G Jarvik, E Larson, JA Pacheco, LJ Rasmussen-Torvik, CB Moore, FW Asselbergs, JH Moore, MD Ritchie, BJ Keating, D Gilbert-Diamond Identifying gene-gene interactions that are highly associated with Body Mass Index using Quantitative Multifactor Dimensionality Reduction (QMDR) BioData Mining 8, 41, 2015

TS Roman, AF Marvelle, MP Fogarty, S Vadlamudi, AJ Gonzalez, ML Buchkovich, JR Huyghe, C Fuchsberger, AU Jackson, Y Wu, M Civelek, AJ Lusis, KJ Gaulton, P Sethupathy, AJ Kangas, P Soininen, M Ala-Korpela, J Kuusisto, FS Collins, M Laakso, M Boehnke, KL Mohlke Multiple hepatic regulatory variants at the GALNT2 high-density lipoprotein cholesterol GWAS locus American Journal of Human Genetics 97, 801-815, 2015

SC Ritchie, P Würtz, AP Nath, G Abraham, AS Havulinna, LG Fearnley, A-P Sarin, AJ Kangas, P Soininen, K Aalto, I Seppälä, E Raitoharju, M Salmi, M Maksimow, S Männistö, M Kähönen, M Juonala, S Ripatti, T Lehtimäki, S Jalkanen, M Perola, O Raitakari, V Salomaa, M Ala-Korpela, J Kettunen, M Inouye The biomarker GlycA is associated with chronic inflammation and predicts long-term risk of severe infection Cell Systems 1, 293-301, 2015

MJ Peters, R Joehanes, LC Pilling, C Schurmann, KN Conneely, J Powell, E Reinmaa, GL Sutphin, A Zhernakova, K Schramm, YA Wilson, S Kobes, T Tukiainen, NABEC/UKBEC Consortium, YF Ramos, HHH Göring, M Fornage, Y Liu, SA Gharib, BE Stranger, PL De Jager, A Aviv, D Levy, JM Murabito, PJ Munson, T Huan, A Hofman, AG Uitterlinden, F Rivadeneira, J van Rooij, L Stolk, L Broer, MMPJ Verbiest, M Jhamai, P Arp, A Metspalu, L Tserel, L Milani, NJ Samani, P Peterson, S Kasela, V Codd, A Peters, CK Ward-Caviness, C Herder, M Waldenberger, M Roden, P Singmann, S Zeilinger, T Illig, G Homuth, HJ Grabe, H Völzke, L Steil, T Kocher, A Murray, D Melzer, H Yaghootkar, S Bandinelli, EK Moses, JW Kent, JE Curran, MP Johnson, S Williams-Blangero, H-J Westra, AF McRae, JA Smith, SLR Kardia, I Hovatta, M Perola, S Ripatti, V Salomaa, AK Henders, NG Martin, AK Smith, D Mehta, EB Binder, KM Nylocks, EM Kennedy, T Klengel, J Ding, AM Suchy-Dicey, DA Enquobahrie, J Brody, JI Rotter, Y-D Chen, J Houwing-Duistermaat, M Kloppenburg, PE Slagboom, Q Helmer, W den Hollander, S Bean, T Raj, N Bakhshi, QP Wang, LJ Oyston, BM Psaty, RP Tracy, GW Montgomery, ST Turner, J Blangero, I Meulenbelt, KJ Ressler, J Yang, L Franke, J Kettunen, PM Visscher, GG Neely, R Korstanje, RL Hanson, H Prokisch, L Ferrucci, T Esko, A Teumer, JBJ van Meurs, AD Johnson The transcriptional landscape of age in human peripheral blood Nature Communications 6, 8570, 2015

MB Lanktree, CC Elbers, Y Li, G Zhang, Q Duan, KJ Karczewski, Y Guo, V Tragante, KE North, M Cushman, FW Asselbergs, JG Wilson, LA Lange, F Drenos, AP Reiner, MR Barnes, BJ Keating Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration Journal of Lipid Research 56, 1781-6, 2015

KE Beaney, JA Cooper, S Ullah Shahid, W Ahmed, R Qamar, F Drenos, MA Crockard, SE Humphries Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population PLOS ONE 10, e0130754, 2015

JC Chambers, M Loh, B Lehne, A Drong, J Kriebel, V Motta, S Wahl, HR Elliott, F Rota, WR Scott, W Zhang, S-T Tan, G Campanella, M Chadeau-Hyam, L Yengo, RC Richmond, M Adamowicz-Brice, U Afzal, K Bozaoglu, ZY Mok, H Kiat Ng, F Pattou, H Prokisch, MA Rozario, L Tarantini, J Abbott, M Ala-Korpela, B Albetti, O Ammerpohl, PA Bertazzi, C Blancher, R Caiazzo, J Danesh, TR Gaunt, S de Lusignan, C Gieger, T Illig, S Jha, S Jones, J Jowett, AJ Kangas, A Kasturiratne, N Kato, N Kotea, S Kowlessur, J Pitkäniemi, P Punjabi, D Saleheen, C Schaf, J Hampe, S Cauchi, CL Relton, P Froguel, R Soong, P Vineis, M-R Jarvelin, J Scott, H Grallert, V Bollati, P Elliott, MI McCarthy, JS Kooner Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study The Lancet Diabetes & Endocrinology 3, 526-34, 2015

IE Hoefer, S Steffens, M Ala-Korpela, M Bäck, L Badimon, M-L Bochaton-Piallat, CM Boulanger, G Caligiuri, S Dimmeler, J Egido, P C Evans, T Guzik, BR Kwak, U Landmesser, M Mayr, C Monaco, G Pasterkamp, J Tuñón, C Weber Novel methodologies for biomarker discovery in atherosclerosis European Heart Journal 36, 2635-42, 2015

Q Wang, AJ Kangas, P Soininen, M Tiainen, T Tynkkynen, K Puukka, A Ruokonen, J Viikari, M Kähönen, T Lehtimäki, V Salomaa, M Perola, GD Smith, OT Raitakari, M-R Järvelin, P Würtz, J Kettunen, M Ala-Korpela Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates International Journal of Epidemiology 44, 623-37, 2015

M Yang, J Zhang, S Kuittinen, J Vepsäläinen, P Soininen, M Keinänen, A Pappinen Enhanced sugar production from pretreated barley straw by additive xylanase and surfactants in enzymatic hydrolysis for acetone-butanol-ethanol fermentation Bioresource Technology 189, 131-7, 2015

F Drenos, E Grossi, M Buscema, SE Humphries Networks in coronary heart disease genetics as a step towards systems epidemiology PLOS ONE 10, e0125876, 2015

S Ghosh, J Vivar, CP Nelson, C Willenborg, AV Segrè, VP Mäkinen, M Nikpay, J Erdmann, S Blankenberg, C O'Donnell, W März, R Laaksonen, AF Stewart, SE Epstein, SH Shah, CB Granger, SL Hazen, S Kathiresan, MP Reilly, X Yang, T Quertermous, NJ Samani, H Schunkert, TL Assimes, R McPherson Systems genetics analysis of genome-wide association study reveals novel associations between key biological processes and coronary artery disease Arteriosclerosis, Thrombosis, and Vascular Biology 35, 1712-22, 2015

I Surakka, M Horikoshi, R Mägi, AP Sarin, A Mahajan, V Lagou, L Marullo, T Ferreira, B Miraglio, S Timonen, J Kettunen, M Pirinen, J Karjalainen, G Thorleifsson, S Hägg, JJ Hottenga, A Isaacs, C Ladenvall, M Beekman, T Esko, JS Ried, CP Nelson, C Willenborg, S Gustafsson, HJ Westra, M Blades, AJ de Craen, EJ de Geus, J Deelen, H Grallert, A Hamsten, AS Havulinna, C Hengstenberg, JJ Houwing-Duistermaat, E Hyppönen, LC Karssen, T Lehtimäki, V Lyssenko, PK Magnusson, E Mihailov, M Müller-Nurasyid, JP Mpindi, NL Pedersen, BW Penninx, M Perola, TH Pers, A Peters, J Rung, JH Smit, V Steinthorsdottir, MD Tobin, N Tsernikova, EM van Leeuwen, JS Viikari, SM Willems, G Willemsen, H Schunkert, J Erdmann, NJ Samani, J Kaprio, L Lind, C Gieger, A Metspalu, PE Slagboom, L Groop, CM van Duijn, JG Eriksson, A Jula, V Salomaa, DI Boomsma, C Power, OT Raitakari, E Ingelsson, MR Järvelin, U Thorsteinsdottir, L Franke, E Ikonen, O Kallioniemi, V Pietiäinen, CM Lindgren, K Stefansson, A Palotie, MI McCarthy, AP Morris, I Prokopenko, S Ripatti, ENGAGE Consortium The impact of low-frequency and rare variants on lipid levels Nature Genetics 47, 589-97, 2015

HJ Westra, D Arends, T Esko, MJ Peters, C Schurmann, K Schramm, J Kettunen, H Yaghootkar, BP Fairfax, AK Andiappan, Y Li, J Fu, J Karjalainen, M Platteel, M Visschedijk, RK Weersma, S Kasela, L Milani, L Tserel, P Peterson, E Reinmaa, A Hofman, AG Uitterlinden, F Rivadeneira, G Homuth, A Petersmann, R Lorbeer, H Prokisch, T Meitinger, C, Herder, M Roden, H Grallert, S Ripatti, M Perola, AR Wood, D Melzer, L Ferruci, AB Singleton, GD Hernandez, JC Knight, R Melchiotti, B Lee, M Poidinger, F Zolezzi, A Larbi, DY Wang, LH van den Berg, JH Veldink, O Rotzschke, S Makino, V Salomaa, K Strauch, U Völker, JBJ van Meurs, A Metspalu, C Wijmenga, RC Jansen, L Franke Cell specific eQTL analysis without sorting cells PLOS Genetics 8, e1005223, 2015

M Fízelová, M Miilunpohja, AJ Kangas, P Soininen, J Kuusisto, M Ala-Korpela, M Laakso, A Stančáková Associations of multiple lipoprotein and apolipoprotein measures with worsening of hyperglycemia and incident type 2 diabetes in 6,607 non-diabetic Finnish men Atherosclerosis 240, 272-277, 2015

JW Knowles, W Xie, Z Zhang, C Chennemsetty, TL Assimes, J Paananen, O Hansson, J Pankow, MO Goodarzi, I Carcamo-Orive, A Morris, Y-D Chen, V-P Mäkinen, A Ganna, X Guo, F Abbasi, DM Greenawalt, P Lum, C Molony, L Lind, C Lindgren, LJ Raffel, PS Tsao, The RISC Consortium, The ULSAM Study, The EUGENE2 Study, The GUARDIAN Consortium, The SAPPHIRe Study, EE Schadt, JI Rotter, A Sinaiko, G Reaven, X Yang, CA Hsiung, L Groop, HJ Cordell, M Laakso, K Hao, E Ingelsson, TM Frayling, MN Weedon, M Walker, T Quertermous Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene The Journal of Clinical Investigaton 125, 1739-1751, 2015

M Ala-Korpela Serum nuclear magnetic resonance spectroscopy: One more step toward clinical utility Clinical Chemistry 61, 681-683, 2015

S Wahl, S Vogt, F Stückler, J Krumsiek, J Bartel, T Kacprowski, K Schramm, M Carstensen, W Rathmann, M Roden, C Jourdan, AJ Kangas, P Soininen, M Ala-Korpela, U Nöthlings, H Boeing, FJ Theis, C Meisinger, M Waldenberger, K Suhre, G Homuth, C Gieger, G Kastenmüller, T Illig, J Linseisen, A Peters, H Prokisch, C Herder, B Thorand, H Grallert Multi-omic signature of body weight change: results from a population-based cohort study BMC Medicine 13, 48, 2015

P Soininen, AJ Kangas, P Würtz, T Suna, M Ala-Korpela Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics Circulation: Cardiovascular Genetics 8, 192-206, 2015

The Interleukin 1 Genetics Consortium, D Freitag, A Butterworth, J Howson, S Burgess, S Kaptoge, R Young, W Kee Ho, A Wood, M Sweeting, S Watson, J Staley, A Ramond, S Nielsen, P Grande, L Lange, M Bown, G Jones, R Scott, E Porcu, G Thorleifsson, L Zeng, T Kessler, M Nikpay, R Do, W Zhang, J Hopewell, M Kleber, G Delgado, A Goel, J Bis, A Smith, L Qu, FN van't Hof, P de Bakker, A Baas, A van Rij, G Tromp, H Kuivaniemi, M Ritchie, S Verma, D Crawford, J Malinowski, M de Andrade, I Kullo, P Peissig, C McCarty, E Bottinger, O Gottesman, D Crosslin, D Carrell, L Rasmussen-Torvik, J Pacheco, J Huang, N Timpson, J Kettunen, M Ala-Korpela, G Mitchell, A Parsa, I Wilkinson, M Gorski, Y Li, N Franceschini, M Keller, S Ganesh, C Langefeld, L Bruijn, M Brown, D Evans, S Baltic, M Ferreira, H Baurecht, S Weidinger, A Franke, S Lubitz, M Mueller, J Felix, N Smith, M Sudman, S Thompson, E Zeggini, K Panoutsopoulou, M Nalls, A Singleton, C Polychronakos, J Bradfield, H Hakonarson, D Easton, D Thompson, I Tomlinson, M Dunlop, K Hemminki, G Morgan, T Eisen, H Goldschmidt, J Allan, M Henrion, N Whiffin, Y Wang, D Chubb, R Houlston, M Iles, D Bishop, M Law, N Hayward, Y Luo, S Nejentsev, M Barbalic, A Dehghan, D Crossman, S Sanna, N Soranzo, H Markus, N Wareham, D Rader, M Reilly, T Assimes, T Harris, V Gudnason, R Tracy, B Psaty, M Farrall, H Watkins, A Hall, N Samani, W März, R Clarke, R Collins, J Kooner, J Chambers, S Kathiresan, R McPherson, J Erdmann, A Kastrati, H Schunkert, K Stefánsson, U Thorsteinsdottir, J Walston, A Tybjærg-Hansen, D Alam, AAS Majumder, E Di Angelantonio, R Chowdhury, B Nordestgaard, D Saleheen, S Thompson, J Danesh Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis The Lancet Diabetes & Endocrinology 3, 243-253, 2015

T Tillin, AD Hughes, Q Wang, P Würtz, M Ala-Korpela, N Sattar, NG Forouhi, IF Godsland, S Eastwood, PM McKeigue, N Chaturvedi Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study Diabetologia 58, 968-979, 2015

P Würtz, AS Havulinna, P Soininen, T Tynkkynen, D Prieto-Merino, T Tillin, A Ghorbani, A Artati, Q Wang, M Tiainen, AJ Kangas, J Kettunen, J Kaikkonen, V Mikkilä, A Jula, M Kähönen, T Lehtimäki, DA Lawlor, TR Gaunt, AD Hughes, N Sattar, T Illig, J Adamski, TJ Wang, M Perola, S Ripatti, RS Vasan, OT Raitakari RE Gerszten, JP Casas, N Chaturvedi, M Ala-Korpela, V Salomaa Metabolite profiling and cardiovascular event risk: a prospective study of three population-based cohorts Circulation 131, 774-785, 2015

VT Männistö, M Simonen, J Hyysalo, P Soininen, AJ Kangas, D Kaminska, AK Matte, S Venesmaa, P Käkelä, V Kärjä, J Arola, H Gylling, H Cederberg, J Kuusisto, M Laakso, H Yki-Järvinen, M Ala-Korpela, J Pihlajamäki Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans Liver International 35, 1853-61, 2015

PJ Talmud, JA Cooper, RW Morris, F Dudbridge, T Shah, J Engmann, C Dale, J White, S McLachlan, D Zabaneh, A Wong, KK Ong, T Gaunt, MV Holmes, DA Lawlor, M Richards, R Hardy, D Kuh, N Wareham, C Langenberg, Y Ben-Shlomo, SG Wannamethee, MW Strachan, M Kumari, JC Whittaker, F Drenos, M Kivimaki, AD Hingorani, JF Price, SE Humphries Sixty-five common genetic variants and prediction of type 2 diabetes Diabetes 64, 1830-1840, 2015

DI Swerdlow, D Preiss, KB Kuchenbaecker, MV Holmes, JE Engmann, T Shah, R Sofat, S Stender, PC Johnson, RA Scott, M Leusink, N Verweij, SJ Sharp, Y Guo, C Giambartolomei, C Chung, A Peasey, A Amuzu, K Li, J Palmen, P Howard, JA Cooper, F Drenos, YR Li, G Lowe, J Gallacher, MC Stewart, I Tzoulaki, SG Buxbaum, DL van der A, NG Forouhi, NC Onland-Moret, YT van der Schouw, RB Schnabel, JA Hubacek, R Kubinova, M Baceviciene, A Tamosiunas, A Pajak, R Topor-Madry, U Stepaniak, S Malyutina, D Baldassarre, B Sennblad, E Tremoli, U de Faire, F Veglia, I Ford, JW Jukema, RG Westendorp, GJ de Borst, PA de Jong, A Algra, W Spiering, AH der Zee, OH Klungel, A de Boer, PA Doevendans, CB Eaton, JG Robinson, D Duggan, , J Kjekshus, JR Downs, AM Gotto, AC Keech, R Marchioli, G Tognoni, PS Sever, NR Poulter, DD Waters, TR Pedersen, P Amarenco, H Nakamura, JJ McMurray, JD Lewsey, DI Chasman, PM Ridker, AP Maggioni, L Tavazzi, KK Ray, SR Seshasai, JE Manson, JF Price, PH Whincup, RW Morris, DA Lawlor, GD Smith, Y Ben-Shlomo, PJ Schreiner, M Fornage, DS Siscovick, M Cushman, M Kumari, NJ Wareham, WM Verschuren, S Redline, SR Patel, JC Whittaker, A Hamsten, JA Delaney, C Dale, TR Gaunt, A Wong, D Kuh, R Hardy, S Kathiresan, BA Castillo, P van der Harst, EJ Brunner, A Tybjaerg-Hansen, MG Marmot, RM Krauss, M Tsai, J Coresh, RC Hoogeveen, BM Psaty, LA Lange, H Hakonarson, F Dudbridge, SE Humphries, PJ Talmud, M Kivimäki, NJ Timpson, C Langenberg, FW Asselbergs, M Voevoda, M Bobak, H Pikhart, JG Wilson, AP Reiner, BJ Keating, AD Hingorani, N Sattar HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials Lancet 385, 351-361, 2015

CL Fogarty, JK Nieminen, L Peräneva, MI Lassenius, AJ Ahola, MR Taskinen, M Jauhiainen, J Kirveskari, P Pussinen, S Hörkkö, VP Mäkinen, D Gordin, C Forsblom, PH Groop, O Vaarala, M Lehto High-fat meals induce systemic cytokine release without evidence of endotoxemia-mediated cytokine production from circulating monocytes or myeloid dendritic cells Acta Diabetologica 52, 315-322, 2015

MV Holmes, FW Asselbergs, TM Palmer, F Drenos, MB Lanktree, CP Nelson, CE Dale, S Padmanabhan, C Finan, DI Swerdlow, V Tragante, EP van Iperen, S Sivapalaratnam, S Shah, CC Elbers, T Shah, J Engmann, C Giambartolomei, J White, D Zabaneh, R Sofat, S McLachlan, , PA Doevendans, AJ Balmforth, AS Hall, KE North, B Almoguera, RC Hoogeveen, M Cushman, M Fornage, SR Patel, S Redline, DS Siscovick, MY Tsai, KJ Karczewski, MH Hofker, WM Verschuren, ML Bots, YT van der Schouw, O Melander, AF Dominiczak, R Morris, Y Ben-Shlomo, J Price, M Kumari, J Baumert, A Peters, B Thorand, W Koenig, TR Gaunt, SE Humphries, R Clarke, H Watkins, M Farrall, JG Wilson, SS Rich, PI de Bakker, LA Lange, G Davey Smith, AP Reiner, PJ Talmud, M Kivimäki, DA Lawlor, F Dudbridge, NJ Samani, BJ Keating, AD Hingorani, JP Casas Mendelian randomization of blood lipids for coronary heart disease European Heart Journal 36, 539-550, 2015

2014

P Würtz, Q Wang, AJ Kangas, RC Richmond, J. Skarp, M Tiainen, T Tynkkynen, P Soininen, AS Havulinna, M Kaakinen, JS Viikari, MJ Savolainen, M Kähönen, T Lehtimäki, S Männistö, S Blankenberg, T Zeller, J Laitinen, A Pouta, P Mäntyselkä, M Vanhala, P Elliott, KH Pietiläinen, S Ripatti, V Salomaa, OT Raitakari, MR Järvelin, G Davey Smith, M Ala-Korpela Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change PLOS Medicine 11, e1001765, 2014

AV Ahola-Olli, N Pitkänen, J Kettunen, MK Oikonen, V Mikkilä, T Lehtimäki, M Kähönen, K Pahkala, H Niinikoski, A Kangas, P Soininen, M Ala-Korpela, JS Viikari, T Rönnemaa, O Simell, OT Raitakari Interactions between genetic variants and dietary lipid composition - effects on circulating LDL-cholesterol in children The American Journal of Clinical Nutrition 100, 1569-77, 2014

VT Männistö, M Simonen, P Soininen, M Tiainen, AJ Kangas, D Kaminska, S Venesmaa, P Käkelä, V Kärjä, H Gylling, M Ala-Korpela, J Pihlajamäki Lipoprotein subclass metabolism in nonalcoholic steatohepatitis Journal of Lipid Research 55, 2676-84, 2014

MM Fashe, RO Juvonen, A Petsalo, M Rahnasto-Rilla, S Auriola, P Soininen, J Vepsäläinen, M Pasanen Identification of a new reactive metabolite of pyrrolizidine alkaloid retrorsine: (3H-Pyrrolizin-7-yl)methanol Chemical Research in Toxicology 27, 1950-7, 2014

K Auro, A Joensuu, K Fischer, J Kettunen, P Salo, H Mattsson, M Niironen, J Kaprio, JG Eriksson, T Lehtimäki, O Raitakari, A Jula, A Tiitinen, M Jauhiainen, P Soininen, AJ Kangas, M Kähönen, AS Havulinna, M Ala-Korpela, V Salomaa, A Metspalu, M Perola A metabolic view on menopause and ageing Nature Communications 5, 4708, 2014

J Saksi, P Ijäs, MI Mäyränpää, K Nuotio, PM Isoviita, J Tuimala, E Lehtonen-Smeds, M Kaste, A Jula, J Sinisalo, MS Nieminen, ML Lokki, M Perola, AS Havulinna, V Salomaa, J Kettunen, M Jauhiainen, PT Kovanen, PJ Lindsberg The low-expression variant of fatty acid-binding protein 4 favors reduced manifestations of atherosclerotic disease and increased plaque stability Circulation: Cardiovascular Genetics 7, 588-598, 2014

HM Ollila, J Kettunen, O Pietiläinen, V Aho, K Silander, E Kronholm, M Perola, J Lahti, K Räikkönen, E Widen, A Palotie, JG Eriksson, T Partonen, J Kaprio, V Salomaa, O Raitakari, T Lehtimäki, M Sallinen, M Härmä, T Porkka-Heiskanen, T Paunio Genome-wide association study of sleep duration in the Finnish population Journal of Sleep Research 23, 609-18, 2014

LJ Cramp, RP Evershed, M Lavento, P Halinen, K Mannermaa, M Oinonen, J Kettunen, M Perola, P Onkamo, V Heyd Neolithic dairy farming at the extreme of agriculture in Northern Europe Proceedings. Biological Sciences / The Royal Society 281, 20140819, 2014

ET Lim, P Würtz, AS Havulinna, P Palta, T Tukiainen, K Rehnström, T Esko, R Mägi, M Inouye, T Lappalainen, Y Chan, RM Salem, M Lek, J Flannick, X Sim, A Manning, C Ladenvall, S Bumpstead, E Hämäläinen, K Aalto, M Maksimow, M Salmi, S Blankenberg, D Ardissino, S Shah, B Horne, R McPherson, GK Hovingh, MP Reilly, H Watkins, A Goel, M Farrall, D Girelli, AP Reiner, NO Stitziel, S Kathiresan, S Gabriel, JC Barrett, T Lehtimäki, M Laakso, L Groop, J Kaprio, M Perola, MI McCarthy, M Boehnke, DM Altshuler, CM Lindgren, JN Hirschhorn, A Metspalu, NB Freimer, T Zeller, S Jalkanen, S Koskinen, O Raitakari, R Durbin, DG MacArthur, V Salomaa, S Ripatti, MJ Daly, A Palotie, Distribution and medical impact of loss-of-function variants in the Finnish founder population PLoS Genetics 10, e1004494, 2014

C Herder, ML Nuotio, S Shah, S Blankenberg, EJ Brunner, M Carstensen, C Gieger, H Grallert, A Jula, M Kähönen, J Kettunen, M Kivimäki, W Koenig, K Kristiansson, C Langenberg, T Lehtimäki, K Luotola, C Marzi, C Müller, A Peters, H Prokisch, O Raitakari, W Rathmann, M Roden, M Salmi, K Schramm, D Swerdlow, AG Tabak, B Thorand, N Wareham, PS Wild, T Zeller, AD Hingorani, DR Witte, M Kumari, M Perola, V Salomaa Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits Diabetes 63, 4343-59, 2014

C Wu, R Lei, M Tiainen, S Wu, Q Zhang, F Pei, X Guo Disordered glycometabolism involved in pathogenesis of Kashin-Beck disease, an endemic osteoarthritis in China Experimental Cell Research 326, 240-50, 2014

DL Cousminer, E Stergiakouli, DJ Berry, W Ang, MM Groen-Blokhuis, A Körner, N Siitonen, I Ntalla, M Marinelli, JR Perry, J Kettunen, R Jansen, I Surakka, NJ Timpson, S Ring, G Mcmahon, C Power, C Wang, M Kähönen, J Viikari, T Lehtimäki, CM Middeldorp, HE Hulshoff Pol, M Neef, S Weise, K Pahkala, H Niinikoski, E Zeggini, K Panoutsopoulou, M Bustamante, BW Penninx, , J Murabito, M Torrent, GV Dedoussis, W Kiess, DI Boomsma, CE Pennell, OT Raitakari, E Hyppönen, G Davey Smith, S Ripatti, MI McCarthy, E Widén, Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty Human Molecular Genetics 23, 4452-64, 2014

P Marttinen, M Pirinen, AP Sarin, J Gillberg, J Kettunen, I Surakka, AJ Kangas, P Soininen, P O'Reilly, M Kaakinen, M Kähönen, T Lehtimäki, M Ala-Korpela, OT Raitakari, V Salomaa, MR Järvelin, S Ripatti, S Kaski Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression Bioinformatics 30, 2026-34, 2014

MI Lassenius, VP Mäkinen, CL Fogarty, L Peräneva, M Jauhiainen, PJ Pussinen, MR Taskinen, J Kirveskari, O Vaarala, JK Nieminen, S Hörkkö, AJ Kangas, P Soininen, M Ala-Korpela, D Gordin, AJ Ahola, C Forsblom, PH Groop, M Lehto Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals Nutrition & Metabolism 11, 28, 2014

HJ Maple, O Scheibner, M Baumert, M Allen, RJ Taylor, RA Garlish, M Bromirski, RJ Burnley Application of the Exactive Plus EMR for automated protein-ligand screening by non-covalent mass spectrometry Rapid Communications in Mass Spectrometry : RCM 28, 1561-8, 2014

E Raitoharju, I Seppälä, N Oksala, LP Lyytikäinen, O Raitakari, J Viikari, M Ala-Korpela, P Soininen, AJ Kangas, M Waldenberger, N Klopp, T Illig, J Leiviskä, BM Loo, N Hutri-Kähönen, M Kähönen, R Laaksonen, T Lehtimäki Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: the cardiovascular risk in Young Finns Study Molecular and Cellular Endocrinology 391, 41-9, 2014

YM Fan, J Hernesniemi, N Oksala, M Levula, E Raitoharju, A Collings, N Hutri-Kähönen, M Juonala, J Marniemi, LP Lyytikäinen, I Seppälä, A Mennander, M Tarkka, AJ Kangas, P Soininen, JP Salenius, N Klopp, T Illig, T Laitinen, M Ala-Korpela, R Laaksonen, J Viikari, M Kähönen, OT Raitakari, T Lehtimäki Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque Scientific Reports 4, 4650, 2014

MR Skilton, N Siitonen, P Würtz, JS Viikari, M Juonala, I Seppälä, T Laitinen, T Lehtimäki, L Taittonen, M Kähönen, DS Celermajer, OT Raitakari High birth weight is associated with obesity and increased carotid wall thickness in young adults: the cardiovascular risk in young Finns study Arteriosclerosis, Thrombosis, and Vascular Biology 34, 1064-8, 2014

P Korsoff, LH Bogl, P Korhonen, AJ Kangas, P Soininen, M Ala-Korpela, RJ Rose, R Kaaja, J Kaprio A comparison of anthropometric, metabolic, and reproductive characteristics of young adult women from opposite-sex and same-sex twin pairs Frontiers in Endocrinology 5, 28, 2014

M Tiainen, P Soininen, R Laatikainen Quantitative Quantum Mechanical Spectral Analysis (qQMSA) of (1)H NMR spectra of complex mixtures and biofluids Journal of Magnetic Resonance 242, 67-78, 2014

M Lankinen, M Kolehmainen, T Jääskeläinen, J Paananen, L Joukamo, AJ Kangas, P Soininen, K Poutanen, H Mykkänen, H Gylling, M Orešič, M Jauhiainen, M Ala-Korpela, M Uusitupa, U Schwab Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: a randomized trial (sysdimet) PLOS ONE 9, e90352, 2014

K Fischer, J Kettunen, P Würtz, T Haller, AS Havulinna, AJ Kangas, P Soininen, T Esko, ML Tammesoo, R Mägi, S Smit, A Palotie, S Ripatti, V Salomaa, M Ala-Korpela, M Perola, A Metspalu Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons PLOS Medicine 11, e1001606, 2014

B Valcárcel, TM Ebbels, AJ Kangas, P Soininen, P Elliot, M Ala-Korpela, MR Järvelin, M de Iorio Genome metabolome integrated network analysis to uncover connections between genetic variants and complex traits: an application to obesity Journal of the Royal Society Interface 11, 20130908, 2014

A Jelenkovic, LH Bogl, RJ Rose, AJ Kangas, P Soininen, M Ala-Korpela, J Kaprio, K Silventoinen Association between serum fatty acids and lipoprotein subclass profile in healthy young adults: Exploring common genetic and environmental factors Atherosclerosis 233, 394-402, 2014

AT Erkkilä, US Schwab, S Lehto, VD de Mello, AJ Kangas, P Soininen, M Ala-Korpela, MI Uusitupa Effect of fatty and lean fish intake on lipoprotein subclasses in subjects with coronary heart disease: A controlled trial Journal of Clinical Lipidology 8, 126-33, 2014

T Tukiainen, M Pirinen, AP Sarin, C Ladenvall, J Kettunen, T Lehtimäki, ML Lokki, M Perola, J Sinisalo, E Vlachopoulou, JG Eriksson, L Groop, A Jula, MR Järvelin, OT Raitakari, V Salomaa, S Ripatti Chromosome x-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation PLOS Genetics 10, e1004127, 2014

P Mäntyselkä, L Niskanen, H Kautiainen, J Saltevo, P Würtz, P Soininen, AJ Kangas, M Ala-Korpela, M Vanhala Cross-sectional and longitudinal associations of circulating omega-3 and omega-6 fatty acids with lipoprotein particle concentrations and sizes: population-based cohort study with 6-year follow-up Lipids in Health and Disease 13, 28, 2014

MI Kurki, EI Gaál, J Kettunen, T Lappalainen, A Menelaou, V Anttila, FN van 't Hof, M von Und Zu Fraunberg, S Helisalmi, M Hiltunen, H Lehto, A Laakso, R Kivisaari, T Koivisto, A Ronkainen, J Rinne, LA Kiemeney, SH Vermeulen, MA Kaunisto, JG Eriksson, A Aromaa, M Perola, T Lehtimäki, OT Raitakari, V Salomaa, M Gunel, ET Dermitzakis, YM Ruigrok, GJ Rinkel, M Niemelä, J Hernesniemi, S Ripatti, PI de Bakker, A Palotie, JE Jääskeläinen High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms PLOS Genetics 10, e1004134, 2014

R Laatikainen, T Hassinen, J Lehtivarjo, M Tiainen, J Jungman, T Tynkkynen, SP Korhonen, M Niemitz, P Poutiainen, O Jääskeläinen, T Väisänen, J Weisell, P Soininen, P Laatikainen, H Martonen, K Tuppurainen Comprehensive strategy for proton chemical shift prediction: linear prediction with nonlinear corrections Journal of Chemical Information and Modeling 54, 419-30, 2014

RM Badeau, MJ Honka, R Lautamäki, M Stewart, AJ Kangas, P Soininen, M Ala-Korpela, P Nuutila Systemic metabolic markers and myocardial glucose uptake in type 2 diabetic and coronary artery disease patients treated for 16 weeks with rosiglitazone, a PPARγ agonist Annals of Medicine 46, 18-23, 2014

TH Soininen, N Jukarainen, P Soininen, SO Auriola, R Julkunen-Tiitto, W Oleszek, A Stochmal, RO Karjalainen, JJ Vepsäläinen Metabolite profiling of Leek (Allium porrum L) cultivars by (1) H NMR and HPLC-MS Phytochemical Analysis 25, 220-8, 2014

O Hemminki, R Immonen, J Närväinen, A Kipar, J Paasonen, KT Jokivarsi, H Yli-Ollila, P Soininen, K Partanen, T Joensuu, S Parvianen, SK Pesonen, A Koski, M Vähä-Koskela, V Cerullo, S Pesonen, OH Gröhn, A Hemminki In vivo magnetic resonance imaging and spectroscopy identifies oncolytic adenovirus responders International Journal of Cancer 134, 2878-90, 2014

2013

L Joukamo, M Lankinen, U Schwab, P Soininen, AJ Kangas, M Kolehmainen, J Paananen, K Poutanen, H Mykkänen, T Seppänen-Laakso, H Gylling, M Oresic, M Ala-Korpela, M Uusitupa [Fatty fish modifies HDL particle size and lipid concentrations] Duodecim 129, 2661-70, 2013

P Würtz, AJ Kangas, P Soininen, T Lehtimäki, M Kähönen, JS Viikari, OT Raitakari, MR Järvelin, G Davey Smith, M Ala-Korpela Lipoprotein subclass profiling reveals pleiotropy in the genetic variants of lipid risk factors for coronary heart disease: a note on Mendelian randomization studies JACC – Journal of the American College of Cardiology 62, 1906-8, 2013

Y Mahendran, H Cederberg, J Vangipurapu, AJ Kangas, P Soininen, J Kuusisto, M Uusitupa, M Ala-Korpela, M Laakso Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men Diabetes Care 36, 3732-8, 2013

PS Larmo, AJ Kangas, P Soininen, HM Lehtonen, JP Suomela, B Yang, J Viikari, M Ala-Korpela, HP Kallio Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial The American Journal of Clinical Nutrition 98, 941-51, 2013

VP Mäkinen, AJ Kangas, P Soininen, P Würtz, PH Groop, M Ala-Korpela Metabolic phenotyping of diabetic nephropathy Clinical Pharmacology and Therapeutics 94, 566-9, 2013

KR Riihinen, VV Mihaleva, T Gödecke, P Soininen, R Laatikainen, JM Vervoort, DC Lankin, GF Pauli ¹H-NMR fingerprinting of Vaccinium vitis-idaea flavonol glycosides Phytochemical Analysis 24, 476-83, 2013

A Jelenkovic, LH Bogl, RJ Rose, AJ Kangas, P Soininen, M Ala-Korpela, J Kaprio, K Silventoinen Association of height and pubertal timing with lipoprotein subclass profile: exploring the role of genetic and environmental effects American Journal of Human Biology 25, 465-72, 2013

P Hovi, E Kajantie, P Soininen, AJ Kangas, AL Järvenpää, S Andersson, JG Eriksson, M Ala-Korpela, K Wehkalampi Lipoprotein subclass profiles in young adults born preterm at very low birth weight Lipids in Health and Disease 12, 57, 2013

Y Mahendran, J Vangipurapu, H Cederberg, A Stancáková, J Pihlajamäki, P Soininen, AJ Kangas, J Paananen, M Civelek, NK Saleem, P Pajukanta, AJ Lusis, LL Bonnycastle, MA Morken, FS Collins, KL Mohlke, M Boehnke, M Ala-Korpela, J Kuusisto, M Laakso Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men Diabetes 62, 3618-26, 2013

LH Bogl, KH Pietiläinen, A Rissanen, AJ Kangas, P Soininen, RJ Rose, M Ala-Korpela, J Kaprio Association between habitual dietary intake and lipoprotein subclass profile in healthy young adults Nutrition, Metabolism, and Cardiovascular Diseases 23, 1071-8, 2013

VP Mäkinen, P Soininen, AJ Kangas, C Forsblom, N Tolonen, LM Thorn, J Viikari, OT Raitakari, M Savolainen, PH Groop, M Ala-Korpela Triglyceride-cholesterol imbalance across lipoprotein subclasses predicts diabetic kidney disease and mortality in type 1 diabetes: the FinnDiane Study Journal of Internal Medicine 273, 383-95, 2013

UM Kujala, VP Mäkinen, I Heinonen, P Soininen, AJ Kangas, TH Leskinen, P Rahkila, P Würtz, V Kovanen, S Cheng, S Sipilä, M Hirvensalo, R Telama, T Tammelin, MJ Savolainen, A Pouta, PF O'Reilly, P Mäntyselkä, J Viikari, M Kähönen, T Lehtimäki, P Elliott, MJ Vanhala, OT Raitakari, MR Järvelin, J Kaprio, H Kainulainen, M Ala-Korpela Long-term leisure-time physical activity and serum metabolome Circulation 127, 340-8, 2013

OT Raitakari, VP Mäkinen, MJ McQueen, J Niemi, M Juonala, M Jauhiainen, V Salomaa, ML Hannuksela, MJ Savolainen, YA Kesäniemi, PT Kovanen, J Sundvall, T Solakivi, BM Loo, J Marniemi, J Hernesniemi, T Lehtimäki, M Kähönen, M Peltonen, J Leiviskä, A Jula, SS Anand, R Miller, S Yusuf, JS Viikari, M Ala-Korpela Computationally estimated apolipoproteins B and A1 in predicting cardiovascular risk Atherosclerosis 226, 245-51, 2013

MR Skilton, V Mikkilä, P Würtz, M Ala-Korpela, KA Sim, P Soininen, AJ Kangas, JS Viikari, M Juonala, T Laitinen, T Lehtimäki, L Taittonen, M Kähönen, DS Celermajer, OT Raitakari Fetal growth, omega-3 (n-3) fatty acids, and progression of subclinical atherosclerosis: preventing fetal origins of disease? The Cardiovascular Risk in Young Finns Study The American Journal of Clinical Nutrition 97, 58-65, 2013

P Würtz, P Soininen, AJ Kangas, T Rönnemaa, T Lehtimäki, M Kähönen, JS Viikari, OT Raitakari, M Ala-Korpela Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults Diabetes Care 36, 648-55, 2013

JJW Mikkonen, M Herrala, P Soininen, R Lappalainen, L Tjäderhane, H Seitsalo, R Niemelä, T Salo, AM Kullaa, S Myllymaa Metabolic profiling of saliva in patients with primary Sjögren's syndrome OMICS Group: Metabolomics 3:128, 2013

N Oksala, I Seppälä, J Hernesniemi, LP Lyytikäinen, M Kähönen, KM Mäkelä, A Reunanen, A Jula, M Ala-Korpela, T Lehtimäki Complementary prediction of cardiovascular events by estimated apo- and lipoprotein concentrations in the working age population The Health 2000 Study Annals of Medicine 45, 141-8, 2013

2012

E Szymańska, J Bouwman, K Strassburg, J Vervoort, AJ Kangas, P Soininen, M Ala-Korpela, J Westerhuis, JP van Duynhoven, DJ Mela, IA Macdonald, RJ Vreeken, AK Smilde, DM Jacobs Gender-dependent associations of metabolite profiles and body fat distribution in a healthy population with central obesity: towards metabolomics diagnostics Omics 16, 652-67, 2012

M Inouye, S Ripatti, J Kettunen, LP Lyytikäinen, N Oksala, PP Laurila, AJ Kangas, P Soininen, MJ Savolainen, J Viikari, M Kähönen, M Perola, V Salomaa, O Raitakari, T Lehtimäki, MR Taskinen, MR Järvelin, M Ala-Korpela, A Palotie, PI de Bakker Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis PLOS Genetics 8, e1002907, 2012

T Tukiainen, P Jylänki, VP Mäkinen, O Gröhn, M Hallikainen, H Soininen, M Kivipelto, K Kaski, PH Groop, MJ Savolainen, T Pirttilä, P Soininen, M Ala-Korpela Mild cognitive impairment associates with concurrent decreases in serum cholesterol and cholesterol-related lipoprotein subclasses The Journal of Nutrition Health and Aging 16, 631-5, 2012

T Tynkkynen, T Hassinen, M Tiainen, P Soininen, R Laatikainen (1) H NMR spectral analysis and conformational behavior of n-alkanes in different chemical environments Magnetic Resonance in Chemistry 50, 598-607, 2012

M Vanhala, J Saltevo, P Soininen, H Kautiainen, AJ Kangas, M Ala-Korpela, P Mäntyselkä Serum omega-6 polyunsaturated fatty acids and the metabolic syndrome: a longitudinal population-based cohort study American Journal of Epidemiology 176, 253-60, 2012

T Tynkkynen, J Mursu, T Nurmi, K Tuppurainen, R Laatikainen, P Soininen NMR protocol for determination of oxidation susceptibility of serum lipids and application of the protocol to a chocolate study Metabolomics 8, 386-398, 2012

VP Mäkinen, T Tynkkynen, P Soininen, C Forsblom, T Peltola, AJ Kangas, PH Groop, M Ala-Korpela Sphingomyelin is associated with kidney disease in type 1 diabetes (The FinnDiane Study) Metabolomics 8, 369-375, 2012

P Mäntyselkä, H Kautiainen, J Saltevo, P Würtz, P Soininen, AJ Kangas, M Ala-Korpela, M Vanhala Weight change and lipoprotein particle concentration and particle size: a cohort study with 65-year follow-up Atherosclerosis 223, 239-43, 2012

J Juhola, M Oikonen, CG Magnussen, V Mikkilä, N Siitonen, E Jokinen, T Laitinen, P Würtz, SS Gidding, L Taittonen, I Seppälä, A Jula, M Kähönen, N Hutri-Kähönen, T Lehtimäki, JS Viikari, M Juonala, OT Raitakari Childhood physical, environmental, and genetic predictors of adult hypertension: the cardiovascular risk in young Finns study Circulation 126, 402-9, 2012

J Wang, A Stančáková, P Soininen, AJ Kangas, J Paananen, J Kuusisto, M Ala-Korpela, M Laakso Lipoprotein subclass profiles in individuals with varying degrees of glucose tolerance: a population-based study of 9399 Finnish men Journal of Internal Medicine 272, 562-72, 2012

P Würtz, M Tiainen, VP Mäkinen, AJ Kangas, P Soininen, J Saltevo, S Keinänen-Kiukaanniemi, P Mäntyselkä, T Lehtimäki, M Laakso, A Jula, M Kähönen, M Vanhala, M Ala-Korpela Circulating metabolite predictors of glycemia in middle-aged men and women Diabetes Care 35, 1749-56, 2012

A Stancáková, M Civelek, NK Saleem, P Soininen, AJ Kangas, H Cederberg, J Paananen, J Pihlajamäki, LL Bonnycastle, MA Morken, M Boehnke, P Pajukanta, AJ Lusis, FS Collins, J Kuusisto, M Ala-Korpela, M Laakso Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men Diabetes 61, 1895-902, 2012

M Ala-Korpela, AJ Kangas, P Soininen Quantitative high-throughput metabolomics: a new era in epidemiology and genetics Genome Medicine 4, 36, 2012

P Würtz, VP Mäkinen, P Soininen, AJ Kangas, T Tukiainen, J Kettunen, MJ Savolainen, T Tammelin, JS Viikari, T Rönnemaa, M Kähönen, T Lehtimäki, S Ripatti, OT Raitakari, MR Järvelin, M Ala-Korpela Metabolic signatures of insulin resistance in 7,098 young adults Diabetes 61, 1372-80, 2012

J Vangipurapu, A Stančáková, T Kuulasmaa, P Soininen, AJ Kangas, M Ala-Korpela, J Kuusisto, M Laakso Association between liver insulin resistance and cardiovascular risk factors Journal of Internal Medicine 272, 402-8, 2012

P Würtz, JR Raiko, CG Magnussen, P Soininen, AJ Kangas, T Tynkkynen, R Thomson, R Laatikainen, MJ Savolainen, J Laurikka, P Kuukasjärvi, M Tarkka, PJ Karhunen, A Jula, JS Viikari, M Kähönen, T Lehtimäki, M Juonala, M Ala-Korpela, OT Raitakari High-throughput quantification of circulating metabolites improves prediction of subclinical atherosclerosis European Heart Journal 33, 2307-16, 2012

K Kristiansson, M Perola, E Tikkanen, J Kettunen, I Surakka, AS Havulinna, A Stancáková, C Barnes, E Widen, E Kajantie, JG Eriksson, J Viikari, M Kähönen, T Lehtimäki, OT Raitakari, AL Hartikainen, A Ruokonen, A Pouta, A Jula, AJ Kangas, P Soininen, M Ala-Korpela, S Männistö, P Jousilahti, LL Bonnycastle, MR Järvelin, J Kuusisto, FS Collins, M Laakso, ME Hurles, A Palotie, L Peltonen, S Ripatti, V Salomaa Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits Circulation Cardiovascular Genetics 5, 242-9, 2012

H Niinikoski, K Pahkala, M Ala-Korpela, J Viikari, T Rönnemaa, H Lagström, E Jokinen, A Jula, MJ Savolainen, O Simell, OT Raitakari Effect of repeated dietary counseling on serum lipoproteins from infancy to adulthood Pediatrics 129, e704-13, 2012

J Kettunen, T Tukiainen, AP Sarin, A Ortega-Alonso, E Tikkanen, LP Lyytikäinen, AJ Kangas, P Soininen, P Würtz, K Silander, DM Dick, RJ Rose, MJ Savolainen, J Viikari, M Kähönen, T Lehtimäki, KH Pietiläinen, M Inouye, MI McCarthy, A Jula, J Eriksson, OT Raitakari, V Salomaa, J Kaprio, MR Järvelin, L Peltonen, M Perola, NB Freimer, M Ala-Korpela, A Palotie, S Ripatti Genome-wide association study identifies multiple loci influencing human serum metabolite levels Nature Genetics 44, 269-76, 2012

VP Mäkinen, T Tynkkynen, P Soininen, T Peltola, AJ Kangas, C Forsblom, LM Thorn, K Kaski, R Laatikainen, M Ala-Korpela, PH Groop Metabolic diversity of progressive kidney disease in 325 patients with type 1 diabetes (the FinnDiane Study) Journal of Proteome Research 11, 1782-90, 2012

T Tukiainen, J Kettunen, AJ Kangas, LP Lyytikäinen, P Soininen, AP Sarin, E Tikkanen, PF O'Reilly, MJ Savolainen, K Kaski, A Pouta, A Jula, T Lehtimäki, M Kähönen, J Viikari, MR Taskinen, M Jauhiainen, JG Eriksson, O Raitakari, V Salomaa, MR Järvelin, M Perola, A Palotie, M Ala-Korpela, S Ripatti Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci Human Molecular Genetics 21, 1444-55, 2012

S M Kuusisto, T Peltola, M Laitinen, L S Kumpula, V-P Mäkinen, T Salonurmi, P Hedberg, M J Savolainen, M L Hannuksela, M Ala-Korpela The interplay between lipoprotein phenotypes, adiponectin, and alcohol consumption Annals of Medicine 44, 513-522, 2012

J Koskinen, CG Magnussen, P Würtz, P Soininen, AJ Kangas, JS Viikari, M Kähönen, BM Loo, A Jula, M Ahotupa, T Lehtimäki, M Ala-Korpela, M Juonala, OT Raitakari Apolipoprotein B, oxidized low-density lipoprotein, and LDL particle size in predicting the incidence of metabolic syndrome: the Cardiovascular Risk in Young Finns study European Journal of Preventive Cardiology 19, 1296-303, 2012

2011

I Surakka, A Isaacs, L C Karssen, P-P Laurila, R P S Middelberg, E Tikkanen, J S Ried, C Lamina, M Mangino, W Igl, J-J Hottenga, V Lagou, P van der Harst, I M Leach, T Esko, Z Kutalik, N W Wainwright, M V Struchalin, A-P Sarin, A J Kangas, J S Viikari, M Perola, T Rantanen, A-K Petersen, P Soininen, Å Johansson, N Soranzo, A C Heath, T Papamarkou, I Prokopenko, A Tönjes, F Kronenberg, A Döring, F Rivadeneira, G W Montgomery, J B Whitfield, M Kähönen, T Lehtimäki, N B Freimer, G Willemsen, E J C de Geus, A Palotie, M S Sandhu, D Waterworth, A Metspalu, M Stumvoll, A G Uitterlinden, A Jula, G Navis, C Wijmenga, B H Wolffenbuttel, M-R Taskinen, M Ala-Korpela, J Kaprio, K O Kyvik, D I Boomsma, N L Pedersen, U Gyllensten, J F Wilson, I Rudan, H Campbell, P P Pramstaller, T D Spector, J C M Witteman, J G Eriksson, V Salomaa, B A Oostra, O T Raitakari, H-E Wichmann, C Gieger, M-R Järvelin, N G Martin, A Hofman, M I McCarthy, L Peltonen, C M van Duijn, Y S Aulchenko, S Ripatti for the ENGAGE Consortium A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol PLOS Genetics 7, e1002333, 2011

M Ala-Korpela, AJ Kangas, M Inouye Genome-wide association studies and systems biology: together at last Trends in Genetics 27, 493-8, 2011

J C Chambers, W Zhang, J Sehmi, X-Z Li, M N Wass, P Van der Harst, H Holm, S Sanna, M Kavousi, S E Baumeister, L J Coin, G-H Deng, C Gieger, N L Heard-Costa, J-J Hottenga, B Kühnel, V Kumar, V Lagou, L-M Liang, J Luan, P Marques Vidal, I Mateo Leach, P O'Reilly, J F Peden, N Rahmioglu, P Soininen, E K Speliotes, X Yuan, G Thorleifsson, B Z Alizadeh, L D Atwood, I B Borrecki, M J Brown, P Charoen, F Cucca, D Das, E J C de Geus, A L Dixon, A Döring, G Ehret, G I Eyjolfsson, M Farrall, N G Forouhi, N Friedrich, W Goessling, D F Gudbjartsson, T B Harris, A-L Hartikainen, S Heath, G M Hirchfield, A Hofman, G Homuth, E Hyppönen, H L A Janssen, T Johnson, A J Kangas, I P Kema, J P Kühn, S Lai, M Lathrop, M M Lerch, Y Li, T J Liang, J-P Lin, R J F Loos, N G Martin, M F Moffat, G W Montgomery, P Munroe, K Musunuru, Y Nakamura, C J O'Donnell, I Olafsson, B W Penninx, A Pouta, B P Prins, I Prokopenko, R Puls, A Ruokonen, M J Savolainen, D Schlessinger, J N L Schouten, U Seedorf, S Sen-Chowdhry, K A Siminovitch, J H Smit, T D Spector, W Tan, T M Teslovich, T Tukiainen, A G Uitterlinden, M M Van der Klauw, R S Vasan, C Wallace, H Wallaschofski, H-E Wichmann, G Willemsen, P Würtz, C Xu, L M Y Armstrong, AlcGen, DIAGRAM, GIANT, Global Lipids Genetics Consortium, The GOLD consortium, ICBP, MAGIC, G R Abecasis, K R Ahmadi, D I Boomsma, M Caulfield, W O Cookson, C M van Duijn, P Froguel, K Matsuda, M I McCarthy, C Meisinger, V Mooser, K H Pietiläinen, G Schumann, H Snieder, M J E Sternberg, R P Stolk, U Thorsteinsdottir, M Uda, G Waeber, N J Wareham, D M Waterworth, H Watkins, J Whitfield, J C M Witteman, B H R Wolffenbuttel, C S Fox, M Ala-Korpela, K Stefansson, P Vollenweider, H Völzke, E E Schadt, J Scott, M-R Järvelin, P Elliott, J S Kooner Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma Nature Genetics 43, 1131-8, 2011

B Valcárcel, P Würtz, N-K Seich al Basatena, T Tukiainen, A J Kangas, P Soininen, M-R Järvelin, M Ala-Korpela, T M Ebbels, M de Iorio A differential network approach to exploring differences between biological states: an application to prediabetes PLOS ONE 6, e24702, 2011

The International Consortium for Blood Pressure Genome-wide Association Studies: G B Ehret, P B Munroe, K M Rice, M Bochud, A D Johnson, D I Chasman, A V Smith, M D Tobin, G C Verwoert, S-J Hwang, V Pihur, P Vollenweider, P F O'Reilly, N Amin, J L Bragg-Gresham, A Teumer, N L Glazer, L Launer, J H Zhao, Y Aulchenko, S Heath, S Sõber, A Parsa, J Luan, P Arora, A Dehghan, F Zhang, G Lucas, A A Hicks, A U Jackson, J F Peden, T Tanaka, S H Wild, I Rudan, W Igl, Y Milaneschi, A N Parker, C Fava, J C Chambers, E R Fox, M Kumari, M J Go, P van der Harst, W H L Kao, M Sjögren, D G Vinay, M Alexander, Y Tabara, S Shaw-Hawkins, P H Whincup, Y Liu, G Shi, J Kuusisto, B Tayo, M Seielstad, X Sim, K-D H Nguyen, T Lehtimäki, G Matullo, Y Wu, T R Gaunt, N C Onland-Moret, M N Cooper, C G P Platou, E Org, R Hardy, S Dahgam, J Palmen, V Vitart, P S Braund, T Kuznetsova, C S P M Uiterwaal, A Adeyemo, W Palmas, H Campbell, B Ludwig, M Tomaszewski, I Tzoulaki, N D Palmer, CARDIoGRAM consortium, CKDGen Consortium, KidneyGen Consortium, EchoGen consortium, CHARGE-HF consortium, T Aspelund, M Garcia, Y-P C Chang, J R O'Connell, N I Steinle, D E Grobbee, D E Arking, S L Kardia, A C Morrison, D Hernandez, S Najjar, W L McArdle, D Hadley, M J Brown, J M Connell, A D Hingorani, I N M Day, D A Lawlor, J P Beilby, R W Lawrence, R Clarke, J C Hopewell, H Ongen, A W Dreisbach, Y Li, J H Young, J C Bis, M Kähönen, J Viikari, L S Adair, N R Lee, M-H Chen, M Olden, C Pattaro, J A H Bolton, A Kâšâttgen, S Bergmann, V Mooser, N Chaturvedi, T M Frayling, M Islam, T H Jafar, J Erdmann, S R Kulkarni, S R Bornstein, J Grässler, L Groop, B F Voight, J Kettunen, P Howard, A Taylor, S Guarrera, F Ricceri, V Emilsson, A Plump, I Barroso, K-T Khaw, A B Weder, S C Hunt, Y V Sun, R N Bergman, F S Collins, L L Bonnycastle, L J Scott, H M Stringham, L Peltonen, M Perola, E Vartiainen, S-M Brand, J A Staessen, T J Wang, P R Burton, M S Artigas, Y Dong, H Snieder, X Wang, H Zhu, K K Lohman, M E Rudock, S R Heckbert, N L Smith, K L Wiggins, A Doumatey, D Shriner, G Veldre, M Viigimaa, S Kinra, D Prabhakaran, V Tripathy, C D Langefeld, A Rosengren, D S Thelle, A M Corsi, A Singleton, T Forrester, G Hilton, C A McKenzie, T Salako, N Iwai, Y Kita, T Ogihara, T Ohkubo, T Okamura, H Ueshima, S Umemura, S Eyheramendy, T Meitinger, H-E Wichmann, Y S Cho, H-L Kim, J-Y Lee, J Scott, J S Sehmi, W Zhang, B Hedblad, P Nilsson, G D Smith, A Wong, N Narisu, A Stančáková, L J Raffel, J Yao, S Kathiresan, C O'Donnell, S M Schwartz, M A Ikram, W T Longstreth Jr, T H Mosley, S Seshadri, N R G Shrine, L V Wain, M A Morken, A J Swift, J Laitinen, I Prokopenko, P Zitting, J A Cooper, S E Humphries, J Danesh, A Rasheed, A Goel, A Hamsten, H Watkins, S J L Bakker, W H van Gilst, C S Janipalli, K R Mani, C S Yajnik, A Hofman, F US Mattace-Raso, B A Oostra, A Demirkan, A Isaacs, F Rivadeneira, E G Lakatta, M Orru, A Scuteri, M Ala-Korpela, A J Kangas, L-P Lyytikäinen, P Soininen, T Tukiainen, P Würtz, R T-H Ong, M Dörr, H K Kroemer, U Völker, H Völzke, P Galan, S Hercberg, M Lathrop, D Zelenika, P Deloukas, M Mangino, T D Spector, G Zhai, J F Meschia, M A Nalls, P Sharma, J Terzic, M J K Kumar, M Denniff, E Zukowska-Szczechowska, L E Wagenknecht, F G R Fowkes, F J Charchar, P E H Schwarz, C Hayward, X Guo, C Rotimi, M L Bots, E Brand, N J Samani, O Polasek, P J Talmud, F Nyberg, D Kuh, M Laan, K Hveem, L J Palmer, Y T van der Schouw, J P Casas, K L Mohlke, P Vineis, O Raitakari, S K Ganesh, T Y Wong, E S Tai, R S Cooper, M Laakso, D C Rao, T B Harris, R W Morris, A F Dominiczak, M Kivimaki, M G Marmot, T Miki, D Saleheen, G R Chandak, J Coresh, G Navis, V Salomaa, B-G Han, X Zhu, J S Kooner, O Melander, P M Ridker, S Bandinelli, U B Gyllensten, A F Wright, J F Wilson, L Ferrucci, M Farrall, J Tuomilehto, P P Pramstaller, R Elosua, N Soranzo, E J G Sijbrands, D Altshuler, R J F Loos, A R Shuldiner, C Gieger, P Meneton, A G Uitterlinden, N J Wareham, V Gudnason, J I Rotter, R Rettig, M Uda, D P Strachan, J C M Witteman, A-L Hartikainen, J S Beckmann, E Boerwinkle, R S Vasan, M Boehnke, M G Larson, M-R Järvelin, B M Psaty, G R Abecasis, A Chakravarti, P Elliott, C M van Duijn, C Newton-Cheh, D Levy, M J Caulfield, T Johnson Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk Nature 478, 103-9, 2011

M Ala-Korpela, V Salomaa, O M Kvalheim Clinical and epidemiological metabonomics Journal of Biomedicine & Biotechnology 2011, 843150, 2011

M Juonala, J Juhola, CG Magnussen, P Würtz, JS Viikari, R Thomson, I Seppälä, J Hernesniemi, M Kähönen, T Lehtimäki, M Hurme, R Telama, V Mikkilä, C Eklund, L Räsänen, M Hintsanen, L Keltikangas-Järvinen, M Kivimäki, OT Raitakari Childhood environmental and genetic predictors of adulthood obesity: the cardiovascular risk in young Finns study The Journal of Clinical Endocrinology and Metabolism 96, E1542-9, 2011

V Kumar, S J Butcher, K Öörni, P Engelhardt, J Heikkonen, K Kaski, M Ala-Korpela, P T Kovanen Three-dimensional cryoEM reconstruction of native LDL particles to 16Å resolution at physiological body temperature PLOS ONE 6, e18841, 2011

A Stančáková, J Paananen, P Soininen, A J Kangas, L L Bonnycastle, M A Morken, F S Collins, A U Jackson, M L Boehnke, J Kuusisto, M Ala-Korpela, M Laakso Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men Diabetes 60, 1608-16, 2011

B E Haas, D Weissglas-Volkov, C A Aguilar-Salinas, E Nikkola, L Vergnes, I Cruz-Bautista, L Riba, A Stancakova, J Kuusisto, P Soininen, A J Kangas, M Ala-Korpela, T Tusie-Luna, M Laakso, P Pajukanta Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles Arteriosclerosis, Thrombosis, and Vascular Biology 31, 1201-7, 2011

Q Wang, HD Li, QS Xu, YZ Liang Noise incorporated subwindow permutation analysis for informative gene selection using support vector machines The Analyst 136, 1456-63, 2011

M Vanhala, L S Kumpula, P Soininen, A J Kangas, M Ala-Korpela, H Kautiainen, P Mäntyselkä, J Saltevo High serum adiponectin is associated with favorable lipoprotein subclass profile in 64-year follow-up European Journal of Endocrinology 164, 549-52, 2011

P Würtz, P Soininen, A J Kangas, V-P Mäkinen, P-H Groop, M J Savolainen, M Juonala, J S Viikari, M Kähönen, T Lehtimäki, O T Raitakari, M Ala-Korpela Characterization of systemic metabolic phenotypes associated with subclinical atherosclerosis Molecular BioSystems 7, 385-93, 2011

T Suna Finnish national archive of health information (KanTa): General concepts and information model Fujitsu Scientific & Technical Journal 47, 49-57, 2011

2010

M Inouye, J Kettunen, P Soininen, K Silander, S Ripatti, L S Kumpula, A Jula, J Leiviskä, E Hämäläinen, P Jousilahti, A J Kangas, S Männistö, M J Savolainen, A Jula, J Leiviskä, A Palotie, V Salomaa, M Perola, M Ala-Korpela, L Peltonen Metabonomic, transcriptomic, and genomic variation of a population cohort Molecular Systems Biology 6, 441, 2010

P Würtz, A Annila Ecological succession as an energy dispersal process Bio Systems 100, 70-8, 2010

T Kangas-Kontio, A Huotari, H Ruotsalainen, K-H Herzig, M Tamminen, M Ala-Korpela, M J Savolainen, S Kakko Genetic and environmental determinants of total and high-molecular weight adiponectin in families with low HDL-cholesterol and early onset coronary heart disease Atherosclerosis 210, 479-85, 2010

M Tiainen, H Maaheimo, P Soininen, R Laatikainen 13C isotope effects on 1H chemical shifts: NMR spectral analysis of 13C-labelled D-glucose and some 13C-labelled amino acids Magnetic Resonance in Chemistry 48, 117-22, 2010

J Weisell, M Hyvönen, J Vepsäläinen, L Alhonen, TA Keinänen, AR Khomutov, P Soininen Novel isosteric charge-deficient spermine analogue--1,12-diamino-3,6,9-triazadodecane: synthesis, pK(a) measurement and biological activity Amino Acids 38, 501-7, 2010

J Pirkola, M Vääräsmäki, M Ala-Korpela, A Bloigu, D Canoy, A-L Hartikainen, M Leinonen, S Miettola, M Paldanius, T H Tammelin, M-R Järvelin, A Pouta Low-grade, systemic inflammation in adolescents: association with early-life factors, gender, and lifestyle American Journal of Epidemiology 171, 72-82, 2010

L S Kumpula, S M Mäkelä, V-P Mäkinen, A Karjalainen, J M Liinamaa, K Kaski, M J Savolainen, M L Hannuksela, M Ala-Korpela Characterization of metabolic interrelationships and in silico phenotyping of lipoprotein particles using self-organizing maps Journal of Lipid Research 51, 431-9, 2010

M Toivanen, S Huttunen, J Duricová, P Soininen, R Laatikainen, V Loimaranta, S Haataja, J Finne, S Lapinjoki, C Tikkanen-Kaukanen Screening of binding activity of Streptococcus pneumoniae, Streptococcus agalactiae and Streptococcus suis to berries and juices Phytotherapy Research 24 Suppl 1, S95-101, 2010

Lundbom J, M Kolehmainen, L Pulkkinen, P Soininen, M Tiainen, U Schwab, M Uusitupa, M Tammi Mid-infrared spectroscopy and multivariate curve resolution for analyzing human adipose tissue triacylglycerols European Journal of Lipid Science and Technology 112, 1308–1314, 2010

2009

M Ala-Korpela, P Soininen, M J Savolainen Letter by Ala-Korpela et al regarding article, "Lipoprotein particle profiles by nuclear magnetic resonance compared with standard lipids and apolipoproteins in predicting incident cardiovascular disease in women" Circulation 120, e149; author reply e150, 2009

V-P Mäkinen, C Forsblom, L M Thorn, J Wadén, K Kaski, M Ala-Korpela, P-H Groop Network of vascular diseases, death and biochemical characteristics in a set of 4,197 patients with type 1 diabetes (the FinnDiane Study) Cardiovascular Diabetology 8, 54, 2009

P Soininen, A J Kangas, P Würtz, T Tukiainen, T Tynkkynen, R Laatikainen, M-R Järvelin, M Kähönen, T Lehtimäki, J Viikari, O T Raitakari, M J Savolainen, M Ala-Korpela High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism Analyst 134, 1781-5, 2009

T Tynkkynen, M Tiainen, P Soininen, R Laatikainen From proton nuclear magnetic resonance spectra to pH Assessment of 1H NMR pH indicator compound set for deuterium oxide solutions Analytica Chimica Acta 648, 105-12, 2009

K Lähdesmäki, R Plihtari, P Soininen, E Hurt-Camejo, M Ala-Korpela, K Oörni, PT Kovanen Phospholipase A(2)-modified LDL particles retain the generated hydrolytic products and are more atherogenic at acidic pH Atherosclerosis 207, 352-9, 2009

K Hanhineva, P Soininen, MJ Anttonen, H Kokko, I Rogachev, A Aharoni, R Laatikainen, S Kärenlampi NMR and UPLC-qTOF-MS/MS characterisation of novel phenylethanol derivatives of phenylpropanoid glucosides from the leaves of strawberry (Fragaria x ananassa cv Jonsok) Phytochemical Analysis 20, 353-64, 2009

J Niemi, VP Mäkinen, J Heikkonen, L Tenkanen, Y Hiltunen, ML Hannuksela, M Jauhiainen, C Forsblom, MR Taskinen, YA Kesäniemi, MJ Savolainen, K Kaski, PH Groop, PT Kovanen, M Ala-Korpela Estimation of VLDL, IDL, LDL, HDL2, apoA-I, and apoB from the Friedewald inputs--apoB and IDL, but not LDL, are associated with mortality in type 1 diabetes Annals of Medicine 41, 451-61, 2009

T Liimatainen, JM Hakumäki, RA Kauppinen, M Ala-Korpela Monitoring of gliomas in vivo by diffusion MRI and (1)H MRS during gene therapy-induced apoptosis: interrelationships between water diffusion and mobile lipids NMR in Biomedicine 22, 272-9, 2009

2008

T Tukiainen, T Tynkkynen, VP Mäkinen, P Jylänki, A Kangas, J Hokkanen, A Vehtari, O Gröhn, M Hallikainen, H Soininen, M Kivipelto, PH Groop, K Kaski, R Laatikainen, P Soininen, T Pirttilä, M Ala-Korpela A multi-metabolite analysis of serum by 1H NMR spectroscopy: early systemic signs of Alzheimer's disease Biochemical and Biophysical Research Communications 375, 356-61, 2008

S Singh, A Jhingran, A Sharma, AR Simonian, P Soininen, J Vepsalainen, AR Khomutov, R Madhubala Novel agmatine analogue, gamma-guanidinooxypropylamine (GAPA) efficiently inhibits proliferation of Leishmania donovani by depletion of intracellular polyamine levels Biochemical and Biophysical Research Communications 375, 168-72, 2008

LS Kumpula, JM Kumpula, MR Taskinen, M Jauhiainen, K Kaski, M Ala-Korpela Reconsideration of hydrophobic lipid distributions in lipoprotein particles Chemistry and Physics of Lipids 155, 57-62, 2008

VP Mäkinen, C Forsblom, LM Thorn, J Wadén, D Gordin, O Heikkilä, K Hietala, L Kyllönen, J Kytö, M Rosengård-Bärlund, M Saraheimo, N Tolonen, M Parkkonen, K Kaski, M Ala-Korpela, PH Groop, Metabolic phenotypes, vascular complications, and premature deaths in a population of 4,197 patients with type 1 diabetes Diabetes 57, 2480-7, 2008

SM Mäkelä, M Jauhiainen, M Ala-Korpela, J Metso, TM Lehto, MJ Savolainen, ML Hannuksela HDL2 of heavy alcohol drinkers enhances cholesterol efflux from raw macrophages via phospholipid-rich HDL 2b particles Alcoholism, Clinical and Experimental Research 32, 991-1000, 2008

VP Mäkinen, P Soininen, C Forsblom, M Parkkonen, P Ingman, K Kaski, PH Groop, , M Ala-Korpela 1H NMR metabonomics approach to the disease continuum of diabetic complications and premature death Molecular Systems Biology 4, 167, 2008

M Tiainen, H Maaheimo, M Niemitz, P Soininen, R Laatikainen Spectral analysis of 1H coupled 13C spectra of the amino acids: adaptive spectral library of amino acid 13C isotopomers and positional fractional 13C enrichments Magnetic Resonance in Chemistry 46, 125-37, 2008

M Ala-Korpela Critical evaluation of 1H NMR metabonomics of serum as a methodology for disease risk assessment and diagnostics Clinical Chemistry and Laboratory Medicine 46, 27-42, 2008

NM Jukarainen, SP Korhonen, MP Laakso, MA Korolainen, M Niemitz, P Soininen, K Tuppurainen, J Vepsäläinen, T Pirttilä, R Laatikainen Quantification of 1H NMR spectra of human cerebrospinal fluid: a protocol based on constrained total-line-shape analysis Metabolomics 4(2), 150-160, 2008

2007

M Ala-Korpela Potential role of body fluid 1H NMR metabonomics as a prognostic and diagnostic tool Expert Review of Molecular Diagnostics 7, 761-73, 2007

P Soininen, K Oörni, H Maaheimo, R Laatikainen, PT Kovanen, K Kaski, M Ala-Korpela 1H NMR at 800 MHz facilitates detailed phospholipid follow-up during atherogenic modifications in low density lipoproteins Biochemical and Biophysical Research Communications 360, 290-4, 2007

A Vehtari, VP Mäkinen, P Soininen, P Ingman, SM Mäkelä, MJ Savolainen, ML Hannuksela, K Kaski, M Ala-Korpela A novel Bayesian approach to quantify clinical variables and to determine their spectroscopic counterparts in 1H NMR metabonomic data BMC Bioinformatics 8 Suppl 2, S8, 2007

V-P Mäkinen, P-H Groop, M Ala-Korpela Metabonomik – på väg mot individuell riskbedömning (in Swedish) Finska Läkaresällskapets Handlingar 167, 40-46, 2007

T Suna, A Salminen, P Soininen, R Laatikainen, P Ingman, S Mäkelä, MJ Savolainen, ML Hannuksela, M Jauhiainen, MR Taskinen, K Kaski, M Ala-Korpela 1H NMR metabonomics of plasma lipoprotein subclasses: elucidation of metabolic clustering by self-organising maps NMR in Biomedicine 20, 658-72, 2007

M Ala-Korpela, N Lankinen, A Salminen, T Suna, P Soininen, R Laatikainen, P Ingman, M Jauhiainen, MR Taskinen, K Héberger, K Kaski The inherent accuracy of 1H NMR spectroscopy to quantify plasma lipoproteins is subclass dependent Atherosclerosis 190, 352-8, 2007

M Pakkala, C Hekim, P Soininen, J Leinonen, H Koistinen, J Weisell, UH Stenman, J Vepsäläinen, A Närvänen Activity and stability of human kallikrein-2-specific linear and cyclic peptide inhibitors Journal of Peptide Science 13, 348-53, 2007

2006

VP Mäkinen, P Soininen, C Forsblom, M Parkkonen, P Ingman, K Kaski, PH Groop, M Ala-Korpela, Diagnosing diabetic nephropathy by 1H NMR metabonomics of serum Magnetic Resonance Materials in Physics, Biology and Medicine 19, 281-96, 2006

M Ala-Korpela, P Sipola, K Kaski Characterization and molecular detection of atherothrombosis by magnetic resonance--potential tools for individual risk assessment and diagnostics Annals of Medicine 38, 322-36, 2006

T Liimatainen, K Lehtimäki, M Ala-Korpela, J Hakumäki Identification of mobile cholesterol compounds in experimental gliomas by (1)H MRS in vivo: effects of ganciclovir-induced apoptosis on lipids FEBS Letters 580, 4746-50, 2006

M Ala-Korpela, P Sipola, K Kaski Characterization and molecular detection of atherothrombosis by magnetic resonance--potential tools for individual risk assessment and diagnostics Annals of Medicine 38, 322-36, 2006

J Holappa, T Nevalainen, P Soininen, M Másson, T Järvinen Synthesis of novel quaternary chitosan derivatives via N-Chloroacyl-6-O-triphenylmethylchitosans Biomacromolecules 7, 407-10, 2006

J Holappa, T Nevalainen, R Safin, P Soininen, T Asplund, T Luttikhedde, M Másson, T Järvinen Novel water-soluble quaternary piperazine derivatives of chitosan: synthesis and characterization Macromolecular Bioscience 6, 139-44, 2006

T Suna, M Hardey, J Huhtinen, Y Hiltunen, K Kaski, J Heikkonen, M Ala-Korpela Self-organising map approach to individual profiles: age, sex and culture in Internet dating Sociological Research Online 11, Issue 1, 2006

NM J Holappa, M Hjálmarsdóttir, M Másson, Ö Rúnarsson, T Asplund, P Soininen, T Nevalainen, T Järvinen Antimicrobial activity of chitosan N-betainates Polymers Carbohydrate 65(1), 114-118, 2006

2005

K Oörni, P Posio, M Ala-Korpela, M Jauhiainen, PT Kovanen Sphingomyelinase induces aggregation and fusion of small very low-density lipoprotein and intermediate-density lipoprotein particles and increases their retention to human arterial proteoglycans Arteriosclerosis, Thrombosis, and Vascular Biology 25, 1678-83, 2005

KM Koistinen, P Soininen, TA Venäläinen, J Häyrinen, R Laatikainen, M Peräkylä, AI Tervahauta, SO Kärenlampi Birch PR-10c interacts with several biologically important ligands Phytochemistry 66, 2524-33, 2005

J Holappa, T Nevalainen, P Soininen, M Elomaa, R Safin, M Másson, T Järvinen N-Chloroacyl-6-O-triphenylmethylchitosans: useful intermediates for synthetic modifications of chitosan Biomacromolecules 6, 858-63, 2005

P Soininen, J Haarala, Vepsäläinen J, M Niemitz, R Laatikainen Strategies for organic impurity quantification by 1H NMR spectroscopy: Constrained total-line-shape fitting Analytica Chimica Acta 542, 178-185, 2005

PA Turhanen, P Soininen, JJ Vepsäläinen One-pot synthesis of 1-[(1-phenyl-1-dialkoxyphosphoryl)-methyl]-2-pyrrofidinone Letters in Chemistry Organic 1(4), 343-345, 2005